Results 101 to 110 of about 40,026,108 (306)

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

HBcrAg Identifies Patients Failing to Achieve HBeAg Seroconversion Treated with Pegylated Interferon Alfa-2b

Chinese Medical Journal, 2016
Background: We aimed to evaluate the usefulness of serum hepatitis B virus core-related antigens (HBcrAg) for predicting hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive chronic hepatitis B patients treated with conventional interferon (IFN)
Hui Ma, Rui-Feng Yang, Xiao-He Li, Qian Jin, Lai Wei   +4 more
doaj   +1 more source

The importance of the serum quantitative levels of hepatitis B surface antigen and hepatitis B e antigen in children with chronic hepatitis B

Turkish Journal of Gastroenterology, 2015
Abstract Background/Aims: We aimed to investigate the clinical importance of quantitative levels of serum hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg), and to detect their correlation with hepatitis B virus (HBV) DNA load, alanine aminotransferase (ALT) levels, hepatic activity index (HAI) and fibrosis scores.
Kaan, Demirören, Halil, Kocamaz, Yaşar, Doğan   +2 more
openaire   +2 more sources

Table 1-1. National notification and print criteria for hepatitis A, hepatitis B, and hepatitis C [PDF]

Table 1-1 describes the national notification criteria for hepatitis A, hepatitis B, and hepatitis C case statuses, based on the current Council of State and Territorial Epidemiologists (CSTE) Position Statements. This table supports general surveillance

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Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels

Indian Journal of Pathology and Microbiology, 2011
Background: Hepatitis B virus (HBV) is a potentially life-threatening liver infection which may progress to liver failure and cirrhosis. Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications ...
Aysegul Sari, Yelda Dere, Betul Pakoz, Aylin Calli, Belkis Unal, Mine Tunakan   +5 more
doaj   +1 more source

High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B

PLoS ONE, 2012
There is no data on the relationship between hepatitis B surface antigen (HBsAg) levels and liver fibrosis in hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB).Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed.
Lai, CL, Yuen, JCH, Hung, IFN, Yuen, MF, Seto, WK, Wong, DKH, Fung, J, Ip, PPC   +7 more
openaire   +6 more sources

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Hyperendemicity and genotype diversity of hepatitis B virus among patients attending the University of Abuja Teaching Hospital, Nigeria

GMS Hygiene and Infection Control
Background: Hepatitis B virus (HBV) infection remains a significant global public health issue, particularly in sub-Saharan Africa, due to inadequate healthcare and research into its genetic epidemiology. This study aims to determine the frequency of HBV
Ugwu, Chinwe Ndidi, Dangana, Amos, Suleiman Chunta, Hassan, Akyala Adamu, Ishaku, Miri, Nanpon, Leviticus Dansura, Mangpin, Samuel, Bwede Eugene, Villeng Gagari, Felix, Adeyemi Ojo, Johnson, Gyang, Nyiri Miriam, Uzoebo, Nkiruka Lynda, Nanbol, Helen Daniel, Nyinishu, Gabriel Bernice, Barde, Aisha Daminso, Abdullahi, Idris Nasir   +14 more
doaj   +1 more source

Rheumatology Informatics System for Effectiveness (RISE) Registry Participation Associated with Significant Gains in Quality Measure Performance: An Interrupted Time Series Analysis

Arthritis &Rheumatology, Accepted Article.
Objective To examine the association between participation in a qualified clinical data registry and quality measure performance. Methods We included practices that joined the American College of Rheumatology's Rheumatology Informatics System for Effectiveness (RISE) registry between 2015 – 2021.
Gabriela Schmajuk, Jessica Fitzpatrick, Jing Li, Stephen Shiboski, Emma Kersey, Jinoos Yazdany   +5 more
wiley   +1 more source