Immune cells use active tugging forces to distinguish affinity and accelerate evolution [PDF]
, 2022 Cells are known to exert forces to sense their physical surroundings for guidance of motion and fate decisions. Here, we propose that cells might do mechanical work to drive their own evolution, taking inspiration from the adaptive immune system. Growing evidence indicates that immune B cells - capable of rapid Darwinian evolution - use cytoskeletal ...
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Positive HBs antigen in the absence of hepatitis B virus infection [PDF]
Annales de Biologie Clinique, John Libbey Eurotext, 2019, 77 (5),
pp.543-548, 2019 French recommendations for the screening of hepatitis B virus (HBV) infection were updated in 2019 with the association of three markers: HBs Ag, anti-HBs Ab and anti-HBc Ab. These three markers allow identification of infected patients, vaccinated patients and patients who have been in contact with HBV. A positive HBs Ag is usually associated with HBV
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Fluctuating fitness shapes the clone size distribution of immune repertoires [PDF]
PNAS 113 (2) 274-279 (2016), 2015 The adaptive immune system relies on the diversity of receptors expressed on the surface of B and T-cells to protect the organism from a vast amount of pathogenic threats. The proliferation and degradation dynamics of different cell types (B cells, T cells, naive, memory) is governed by a variety of antigenic and environmental signals, yet the observed
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Adaptive Learning Expert System for Diagnosis and Management of Viral Hepatitis [PDF]
International journal of artificial intelligence and applications,
2019, Volume 10, Number 2, 2019 Viral hepatitis is the regularly found health problem throughout the world among other easily transmitted diseases, such as tuberculosis, human immune virus, malaria and so on. Among all hepatitis viruses, the uppermost numbers of deaths are result from the long-lasting hepatitis C infection or long-lasting hepatitis B. In order to develop this system,
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Dynamical analysis of a generalized hepatitis B epidemic model and its dynamically consistent discrete model [PDF]
arXiv, 2021 The aim of this work is to study qualitative dynamical properties of a generalized hepatitis B epidemic model and its dynamically consistent discrete model.
arxiv
Mathematical Analysis of Autonomous and Nonautonomous Hepatitis B Virus Transmission Models [PDF]
, 2023 This study presents an improved mathematical model for Hepatitis B Virus (HBV) transmission dynamics by investigating autonomous and nonautonomous cases. The novel model incorporates the effects of medical treatment, allowing for a more comprehensive understanding of HBV transmission and potential control measures.
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The effects of symmetry on the dynamics of antigenic variation [PDF]
J. Math. Biol. 66, 115-137 (2013), 2012 In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of ...
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Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv
Textual analysis of clinical notes on pathology request forms to determine sensitivity and specificity of Hepatitis B and C virus infection status [PDF]
arXiv, 2022 Background: It is not established whether clinical notes provided on pathology request forms are useful as decision support data when assessing Hepatitis B and C viral infection status. Objective: To determine sensitivity, specificity, and predictive value of clinical notes for identifying infection status of Hepatitis B and C.
arxiv
Active tuning of synaptic patterns enhances immune discrimination [PDF]
Phys. Rev. Lett. 121, 238101 (2018), 2018 Immune cells learn about their antigenic targets using tactile sense: during recognition, a highly organized yet dynamic motif, named immunological synapse, forms between immune cells and antigen-presenting cells (APCs). Via synapses, immune cells selectively extract recognized antigen from APCs by applying mechanical pulling forces generated by the ...
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