Results 41 to 50 of about 12,657,081 (210)

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

Uptake of the hepatitis B vaccine among brothel-based female sex workers in Kampala, Uganda

BMC Public Health
Background Hepatitis B is a significant health problem worldwide, particularly among high-risk groups such as female sex workers (FSWs). In Uganda, it is highly recommended that FSWs receive the hepatitis B vaccine.
Joana Nakiggala, Mathias Lwenge, Doreen Nakalembe, Bridget Nagawa Tamale, Aisha Nalugya, Jovan Galiwango, Junior Mike Wejuli, Kenneth Tebandeke, John Bosco Isunju, Richard K. Mugambe, Tonny Ssekamatte   +10 more
doaj   +1 more source

Predictors of Hepatitis B screening and vaccination status of young psychoactive substance users in informal settlements in Kampala, Uganda.

PLoS ONE, 2022
BackgroundYoung psychoactive substance users exhibit high-risk behaviours such as unprotected sexual intercourse, and sharing needles and syringes, which increases their risk of Hepatitis B infection.
Tonny Ssekamatte, John Bosco Isunju, Joan Nankya Mutyoba, Moses Tetui, Richard K Mugambe, Aisha Nalugya, Winnifred K Kansiime, Chenai Kitchen, Wagaba Brenda, Patience Oputan, Justine Nnakate Bukenya, Esther Buregyeya, Simon P S Kibira   +12 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Household survey of hepatitis B vaccine coverage among Brazilian children

, 2009
We conducted a multi-stage household cluster survey to calculate hepatitis B vaccine coverage among children 18-30 months of age in 27 Brazilian cities.
FLANNERY, Brendan, Vaccine Coverage Survey 2007 Grp, LUNA, Expedito J. A., MORAES, Jose Cassio de, VERAS, Maria Amelia S. M.   +4 more
core   +1 more source

Association of early age at establishment of chronic hepatitis B infection with persistent viral replication, liver cirrhosis and hepatocellular carcinoma: a systematic review. [PDF]

, 2013
Age at infection with hepatitis B virus (HBV) is a known risk factor for chronic HBV infection. However, in addition, there is some evidence that early age at infection further increases the risk of primary liver cancer beyond its association with ...
Bottomley, Christian, Andrew J Hall, Hong-Jing Yan, Tsuchiya Naho, Hall, Andrew, Andrew J. Hall (78002), Shimakawa Yusuke, Yan, Hong-Jing, Yusuke Shimakawa, Christian Bottomley, Hall Andrew J., Hall, Andrew J, Yan Hong-Jing, Shimakawa, Yusuke, Tsuchiya, Naho, Naho Tsuchiya, Bottomley Christian, Andrew J. Hall, Yusuke Shimakawa (435296), Hong-Jing Yan (435297), Naho Tsuchiya (211103), Christian Bottomley (144483)   +21 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Physicians Infrequently Adhere to Hepatitis Vaccination Guidelines for Chronic Liver Disease [PDF]

, 2013
Background and Goals:Hepatitis A (HAV) and hepatitis B (HBV) vaccination in patients with chronic liver disease is an accepted standard of care. We determined HAV and HBV vaccination rates in a tertiary care referral hepatology clinic and the impact of ...
Dhiraj Yadav, Behari, J, Yadav, D, Sweeney Kaitlyn, Thudi Kavitha, Yadav Dhiraj, Kavitha Thudi, Jaideep Behari, Sweeney, Kaitlyn, Thudi, K, Behari, Jaideep, Thudi, Kavitha, Behari Jaideep, Yadav, Dhiraj, Kaitlyn Sweeney, Sweeney, K   +15 more
core   +2 more sources

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source