Results 101 to 110 of about 13,643,530 (312)

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Hepatitis B and C infections, and co-infections screening among patients attending a tertiary hospital in Addis Ababa, Ethiopia: a retrospective database study

BMC Gastroenterology
Background Hepatitis B and C virus infection is a continuous public health problem in Ethiopia, with the prevalence of the disease significantly varying across administrative regions.
Balew Arega, Ermiyas Tefera, Kibrom Mesfin, Daniel Achame, Dawit Tolossa, Abenezer Worku, Ermias Kibru, Nebyu Tafasse, Amdemeskel Mersha   +8 more
doaj   +1 more source

Viral hepatitis in female sex workers using the Respondent-Driven Sampling

Revista de Saúde Pública
OBJECTIVE To estimate the prevalence of hepatitis B virus and C virus infections and their genotypes and analyze the risk factors for the markers of exposure to hepatitis B virus in female sex workers in a region of intense sex trade.
Marcos André de Matos, Divânia Dias da Silva França, Megmar Aparecida dos Santos Carneiro, Regina Maria Bringel Martins, Lígia Regina Franco Sansigolo Kerr, Karlla Antonieta Amorim Caetano, Raquel Silva Pinheiro, Lyriane Apolinário de Araújo, Rosa Maria Salani Mota, Marcia Alves Dias de Matos, Ana Rita Coimbra Motta-Castro, Sheila Araújo Teles   +11 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection [PDF]

, 2010
NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill ...
Richard J. Gilson, Dusheiko, G., Gilson, R.J., Dunn Claire, Gilson Richard J., Peppa, D, Patrick T F Kennedy, Ellis, G., Claire Dunn, Celeste Pallant, Dunn, C., Geoffrey Dusheiko, Lorenzo Micco, Dusheiko Geoffrey, Maini Mala K., Micco, L, Ellis, G, Pooja Khanna, Maini, MK, Pallant, C., Micco Lorenzo, Khanna, P, Javaid, A., Gilson, RJ, Micco, L., Mala K Maini, Schurich, A.; id_orcid, Javaid Alia, Khanna Pooja, Schurich, A, Kennedy, P.T.F., Anna Schurich, Pallant, C, Kennedy Patrick T. F., Mala K. Maini, Khanna, P., Peppa Dimitra, Gidon Ellis, Dusheiko, G, Javaid, A, Ellis Gidon, Dimitra Peppa, Dunn, C, Patrick T. F. Kennedy, Pallant Celeste, Maini, M.K., Kennedy, PTF, Alia Javaid, Peppa, D., Schurich Anna, Richard J Gilson   +50 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Hepatitis B vaccination in the Columbian Amazon : effectiveness and factors influencing vaccine coverage [PDF]

A vaccination coverage survey was carried out in the Colombian Amazon, a former high endemic area for hepatitis B, involving 3573 children less than II years old. It was carried out in Leticia, Puerto Narifio, and Araracuara, both urban and rural areas.
De La Hoz, Fernando
core   +1 more source

Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]

, 2012
Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Xiumei Chi, Lv, J., Yu Pan, Zhigang Tian, Niu, J., Juan Lv, Weihua Xiao, Yan, H., Xu, D., Zhengkun Tu, Hu, X., Chi, X., Junqi Niu, Qinglong Jin, Xiao, W., Sun, H., Hou, J., Jinlin Hou, Hongqing Yan, Haibo Sun, Tian, Z., Tu, Z., Xiaoli Hu, Jin, Q., Pan, Y., Damo Xu   +25 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Camacho, F., Perez, E.M., Amin, N., Aguilar, A., David I. Stott, Talavera, A., Arturo Talavera, Raiza Martinez, Frank Camacho, Nevis Amin, Ela M. Perez, Larralde, O.G., Alicia Aguilar, Martinez, R., Osmany G. Larralde, Stott, D.I.   +15 more
core   +1 more source