Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]
, 2011 Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz +5 more
core +1 more source
Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment [PDF]
, 2010 Background Early detection of nonresponders to hepatitis C therapy limits unnecessary exposure to treatment and its side-effects. A recent algorithm combining baseline anti-NS4a antibodies and on-treatment quantitative PCR identified nonresponders to a ...
de Knegt, Robert J +8 more
core +1 more source
Direct-acting antivirals for chronic hepatitis C.
Cochrane Database of Systematic Reviews, 2017 BACKGROUND Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g.
J. Jakobsen +15 more
semanticscholar +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Costs of Treatment, Follow-Up, and Complications of Chronic Hepatitis B and Hepatitis C Infections
Balkan Medical Journal, 2013 Background: Few studies have addressed the indirect costs of chronic hepatitis B and C, and none has assessed the real costs of these conditions, including indirect costs caused by loss of work, in Turkey. Aims: This study therefore analysed the costs of
Fatma Banu Karahasanoğlu +3 more
doaj +1 more source
The influence of hepatic steatosis on the success of antiviral therapy for chronic hepatitis C [PDF]
Vojnosanitetski Pregled, 2017 Background/Aim. Chronic hepatitis C and liver steatosis often appear simultaneously in the same person, and steatosis can lead to worsening of liver disease and reducing the success of the treatment of chronic hepatitis C.
Preveden Tomislav +2 more
doaj +1 more source
Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C [PDF]
, 2018 Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients ...
Breaban, Iulia +12 more
core +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Hepatitis C prevalence in Denmark -an estimate based on multiple national registers
BMC Infectious Diseases, 2012 Background A national survey for chronic hepatitis C has not been performed in Denmark and the prevalence is unknown. Our aim was to estimate the prevalence of chronic hepatitis C from public registers and the proportion of these patients who received ...
Christensen Peer +8 more
doaj +1 more source
Hepatitis C Virus Epidemic Control Using a Nonlinear Adaptive Strategy [PDF]
arXiv, 2020 Hepatitis C is a viral infection that appears as a result of the Hepatitis C Virus (HCV), and it has been recognized as the main reason for liver diseases. HCV incidence is growing as an important issue in the epidemiology of infectious diseases. In the present study, a mathematical model is employed for simulating the dynamics of HCV outbreak in a ...
arxiv