Results 71 to 80 of about 283,809 (263)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Hepatitis B and Hepatitis C Co-infection: Treatment Approaches and A Case Report

Viral Hepatitis Journal
Hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection is a significant health issue worldwide and can accelerate liver damage when they occur together.
Mirkan Bulğak, Tuna Demirdal
doaj   +1 more source

КЛИНИКО-ЛАБОРАТОРНАЯ ХАРАКТЕРИСТИКА ХРОНИЧЕСКИХ ГЕПАТИТОВ И ЦИРРОЗОВ ПЕЧЕНИ РАЗЛИЧНОЙ ЭТИОЛОГИИ

Архивъ внутренней медицины, 2015
The review of literature discusses the clinical and biochemical changes in patients with chronic hepatitis C, chronic hepatitis of alcoholic etiology, chronic hepatitis combined genesis (HCV + alcohol) and cirrhosis in the outcome of hepatitis, liver ...
А. Р. Билалова, В. В. Макашова   +1 more
doaj   +1 more source

CHRONIC HEPATITIS C

The Professional Medical Journal, 2010
Objectives: To know efficacy of combination of standard interferon α2b and ribavirin in chronic hepatitis C. Design: Prospective and analytical. Setting: CMH Bahawalpur. Period: Nov 2008 to Dec 2009. Materials and methods: A total of 126 patients, 104 males and 22 females, fulfilling inclusion and exclusion criteria were started combination treatment ...
SHAUKAT ALI, SYED KHURRAM SHAHZAD, ATIQ UR REHMAN SLEHRIA   +2 more
openaire   +2 more sources

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Development of hepatocellular carcinoma in a patient with chronic hepatitis C and cirrhosis. Сlinical case

Лечащий Врач
Background. Chronic hepatitis C is currently an urgent problem worldwide. According to the World Health Organization, there are currently more than 50 million people living with chronic hepatitis C virus infection, with approximately 1 million new cases ...
I. V. Mannanova, M. A. Kiryakova, Zh. B. Ponezheva, V. V. Makashova, N. A. Antipyat, O. A. Ivanova, V. Lusenina   +6 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Clinical-epidemiological and pathogenetic features of viral hepatitis C in the hemodialysis departments

Трансплантология (Москва), 2019
Background. Today, the programmed hemodialysis belongs to the clinical medicine area where patients are at a constant risk of viral hepatitis infection. This is associated with surgical interventions on the vessels, fairly frequent transfusions of blood ...
R. N. Akalaev, G. Z. Aripkhodzhaeva, S. A. Rashidova, A. N. Abdullaev, K. A. Khashimov   +4 more
doaj   +1 more source

CHRONIC HEPATITIS “C”;

The Professional Medical Journal, 2013
OBJECTIVE: To find spectrum of various dermatological manifestations during hepatitis “C” virus infection in localpopulation of hyderabad. METHODS: This descriptive study was conducted in medicine department of Isra University HospitalHyderabad from January 2011 to June 2012. A total of 325 anti-HCV positive patients were enrolled.
ATIF SITWAT HAYAT, MUHAMMAD ADNAN BAWANY, TARIQ ZAFAR SHAIKH, Adnan Ali Khahro, Shireen Rahat Khanzada   +4 more
openaire   +2 more sources

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source