Results 81 to 90 of about 186,361 (263)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Detección de anticuerpos contra el VHC y los factores de riesgo en la población con acceso a la seguridad social en México

Revista de Gastroenterología de México
Resumen: Introducción y objetivo: La detección y el diagnóstico oportuno del virus de la hepatitis C (VHC) implica identificar la población susceptible de tratamiento, prevenir, limitar complicaciones y evitar contagios.
B. Ríos-Castillo, C. Duque-Molina, G. Borrayo-Sánchez, J.H. Medina-Chávez, E. Pineda-Ruiz, A. Rosales-Piñón, M.R. Niebla-Fuentes, A.M. Santana-Ramírez, S.C. Treviño-Pérez, R. Avilés-Hernández, A. Reyna-Sevilla   +10 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Seroprevalence of hepatitis B, C, and its associated risk factors among clinically suspected patients attending poly and Maraki Health Centers, Gondar City, North West Ethiopia

SAGE Open Medicine
Background: Hepatitis B and C viruses are major global health problems with a high mortality rate, mostly due to serious liver diseases such as liver cirrhosis, liver failure, and hepatocellular carcinoma. The objective of this study was to determine the
Solomon Tesfaye, Adefework Alemu, Endalkachew Bizualem, Daniel Mehabie, Amir Alelign   +4 more
doaj   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Características clínicas y morfológicas de la hepatitis C en donantes

Revista Cubana de Medicina, 2002
Se estudió una serie de 60 sujetos donantes de sangre con presencia de anticuerpos contra el virus C de la hepatitis (Ac VHC). Se trató de identificar la expresión clínica de la enfermedad por VHC en donantes, de conocer los resultados laparoscópicos e ...
Domingo Sabina Molina, Francisco García Valdés, Álvaro Asconegui Moya, Orelvis Martínez López   +3 more
doaj  

Prevalence and Risk Factors of Hepatitis C Virus Antibodies among Inmates in North Central Nigeria: A Cross-Sectional Study

UMYU Journal of Microbiology Research
Hepatitis C is a serious global health concern, with an estimated 189 million cases and 71 million chronic carriers. The lack of data among certain populations in low- and middle-income nations like Nigeria exacerbates the dilemma.
Anthony Tiri John, Murna Ali, Hashimu Zakari, Joseph Anejo-Okopi   +3 more
doaj   +1 more source

A population-based screening for hepatitis C antibodies and active infection using a point-of-care test in a low prevalence area. [PDF]

PLoS One, 2020
Carvalho-Gomes Â, Cubells A, Pallarés C, Hontangas V, Conde I, Di Maira T, Peiró S, Sanfélix-Gimeno G, López-Labrador FX, Berenguer M.   +9 more
europepmc   +1 more source