Results 131 to 140 of about 1,173,658 (399)

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

open access: yesAdvanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi   +18 more
wiley   +1 more source

Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil

open access: yesBrazilian Journal of Infectious Diseases, 2018
Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality.
Guilherme Bricks   +9 more
doaj   +1 more source

The hepatitis C virus: Overview [PDF]

open access: yesHepatology, 1997
Our knowledge of hepatitis C virus (HCV) dates only from 1975, when non- A, non-B hepatitis was first recognized. It was not until 1989 that the genome of the virus was first cloned and sequenced, and expressed viral antigens used to develop serological assays for screening and diagnosis.
openaire   +2 more sources

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

open access: yesAdvanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu   +20 more
wiley   +1 more source

Hepatitis C virus proteins [PDF]

open access: yesWorld Journal of Gastroenterology, 2007
Hepatitis C virus (HCV) encodes a single polyprotein, which is processed by cellular and viral proteases to generate 10 polypeptides. The HCV genome also contains an overlapping +1 reading frame that may lead to the synthesis of an additional protein.
openaire   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

open access: yesAdvanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong   +5 more
wiley   +1 more source

Aspek Virologi Hepatitis C [PDF]

open access: yes, 2003
Hepatitis C resembles hepatitis B epidemiologically and clinically, but not virologically. Hepatitis C virus (HCV) is an RNA virus, it does not integrate into the genome of hepatocyte, the hypervariability of glycoproteins in its envelop makes the host ...
Widura, W. (Widura)
core  

The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses [PDF]

open access: gold, 2018
Sarwat Mahmud   +2 more
openalex   +1 more source

Pathogenesis of hepatitis C virus

open access: yesUirusu, 2007
Hepatitis C virus (HCV) infects approximately 170 million people worldwide including 2 million in Japan and induces serious chronic hepatitis that results in the development of steatosis, cirrhosis and ultimately hepatocellular carcinoma. The current combination therapy using pegylated interferon alpha and a nucleotide analogue ribavirin achieved a ...
Kohji, Moriishi, Yoshiharu, Matsuura
openaire   +3 more sources

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