Results 81 to 90 of about 149,243 (305)

Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity

, 2012
Aim: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined.
Kronenberger Bernd, Stefan Zeuzem, Reichert, David, Kronenberger, Bernd, Martinez, Yolanda, Martinez Yolanda, Bernd Kronenberger, Susser, Simone, Sarrazin, Christoph, Herrmann Eva, Susser Simone, Zeuzem Stefan, Piiper, Albrecht, Christoph Sarrazin, Simone Susser, Reichert David, Piiper Albrecht, Herrmann, Eva, Sarrazin Christoph, Martin-Walter Welker, Welker Martin-Walter, Albrecht Piiper, Eva Herrmann, Welker, Martin-Walter, David Reichert, Zeuzem, Stefan, Yolanda Martinez   +26 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Servo prevalence of hepatitis B and C and HIV in multiple transfusions ß-thalassemia: Result from an only thalassemia day care unit in Kerman-Iran

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Patients with major ß-thalassemia require multi-transfusions for survival. They are at a high risk for blood transfusion transmitted infections, particularly with Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Human immunodeficiency virus (HIV ...
Amir-Hooshang Sheikh-Bardsiri, Amin-Reza Owhadi, Andre M.N. Renzaho, Maryam Delavari   +3 more
doaj  

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +1 more source

Spatial mapping of hepatitis C prevalence in recent injecting drug users in contact with services. [PDF]

, 2011
In developed countries the majority of hepatitis C virus (HCV) infections occur in injecting drug users (IDUs) with prevalence in IDUs often high, but with wide geographical differences within countries.
Morongiu, A, V. D. HOPE, D. DE ANGELIS, Harris, R. J., Morongiu, A., DE Angelis, D, Hickman, Matthew, Ncube, F, R. J. HARRIS, Hope, V. D., Hope, VD, A. MORONGIU, de Angelis, D., Harris, RJ, Hickman, M, Ncube, F., M. HICKMAN, F. NCUBE   +17 more
core   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Risk Factors and Seroprevalence of Hepatitis B, C, and D Virus in Hemodialysis Patients in Istanbul [PDF]

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2014
Introduction: Hemodialysis units pose a risk for transmission of hepatitis viruses. In this study, we aimed to detect the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) in our hospital’s hemodialysis unit and ...
İnci ALP, Derya ÖZTÜRK ENGİN, Naz OĞUZOĞLU, Asuman İNAN, Nurgül CERAN, Nazım DENİZLİ, Seyfi ÖZYÜREK   +6 more
doaj   +1 more source

Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow [PDF]

, 2012
Unsafe injecting practices put injecting drug users (IDUs) at repeat exposure to infection with the hepatitis C virus (HCV). It has not yet been determined if spontaneously clearing one's primary infection influences the risk of reinfection; our aim was ...
Hutchinson, Sharon, Hutchinson, Sharon; id_orcid, Goldberg, David J., Cameron, S.O., Innes, Hamish, McLeod, Allan, Mcdonald, Scott   +6 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

ANALISIS MOLEKULER GENOM VIRUS HEPATITIS C SERTA PERANANNYA DALAM PATOGENESIS INFEKSI

JKS (Jurnal Kedokteran Syiah Kuala), 2012
Abstrak. Virus Hepatitis C (HCV) adalah penyebab Hepatitis C, suatu penyakit yang masih menjadi masalah kesehatan di dunia, khususnya di Indonesia. Virus ini bergenom RNA untai tunggal yang berukuran sekitar 9,6 kilobasa.
Tristia Rinanda
doaj