Results 91 to 100 of about 286,424 (258)
Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis
Advanced Science, EarlyView.A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen +12 more
wiley +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Advanced Science, EarlyView.In HCC, ADISSP sustains IKKβ/NF‐κB signaling by inhibiting PPP1CA‐mediated IKKβ dephosphorylation, thereby inducing the expressions of SLC16A3 and CCL20. SLC16A3‐driven lactate remodeling promotes glycolysis, ferroptosis resistance, and M2 macrophage polarization, whereas CCL20 facilitates macrophage recruitment.
Tuan‐Song Zhang +10 more
wiley +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Advanced Science, EarlyView.TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang +8 more
wiley +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatitis type B is preventable and can be cured
نشریه پرستاری ایران, 2001 Viral hepatitis is one of five infectional factors cause early death in all over the world. Every day at least one million people die because of viral hepatitis. Six hepatitis viruses have been known until now.
Nikpoor
doaj
Hepatitis D virus: update on epidemiology and challenges in China
Zhongguo linchuang yanjiuHepatitis D virus (HDV) infection is a major global public health problem. HDV is a defective subvirus that requires the hepatitis B virus (HBV) for assembly and propagation.
ZOU Huaibin, YAO Chengxuan, DUAN Zhongping, REN Feng, CHEN Yu
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe +8 more
wiley +1 more source
Hepatology, EarlyView., 2022 Graphical abstract summarizing the study design, main results and key findings Abstract Background and Aims Fatty liver disease (FLD) has been associated with excess mortality. Screening for hepatic steatosis (HS) in patients with metabolic dysfunction is therefore recommended by several guidelines, despite a paucity of evidence on the clinical ...
Laurens A. van Kleef +5 more
wiley +1 more source