Results 101 to 110 of about 457,015 (304)

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

The Complex Interplay of Hepatitis D in Patients with Hepatitis B: Letter to the Editor [PDF]

Iranian Journal of Medical Sciences
I read with great interest the article by Safarpour and colleagues on the epidemiology of hepatitis D virus (HDV) and its associated factors in southern Iran.
Kamran Bagheri Lankarani
doaj   +1 more source

Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. [PDF]

, 2008
Hepatitis C virus (HCV) infection is dependent on at least three coreceptors: CD81, scavenger receptor BI (SR-BI), and claudin-1. The mechanism of how these molecules coordinate HCV entry is unknown.
Balfe, Peter, Bassendine, Margaret F, Drummer, Heidi E, Grove, Joe, McKeating, Jane A, Nielsen, Søren, Zhong, Jin   +6 more
core   +3 more sources

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Genotyping of occult hepatitis B virus infection in Egyptian hemodialysis patients without hepatitis C virus infection

Journal of Infection and Public Health, 2016
Summary: Background: Occult hepatitis B viral infection is the presence of hepatitis B viral nucleic acids in the serum and/or liver in the absence of hepatitis B surface antigen.
Mona A. Esmail, Wafaa K.M. Mahdi, Rasha M. Khairy, Nilly H. Abdalla   +3 more
doaj   +1 more source

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog [PDF]

, 2009
Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear.
Asahina, Kinji, Deshaies, Raymond, Duan, Lewei, Dynnyk, Alla, Govindarajan, Sugantha, Lai, Michael M.-C., Liu, Helene Minyi, Machida, Keigo, Miyake, Kensuke, Mkrtchyan, Hasmik, Ou, Jing-hsiung James, Ray, Ratna, Seki, Ekihiro, Tsukamoto, Hidekazu   +13 more
core   +2 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Detection of HBV Genotypes of Tumor Tissues and Serum by A Fluorescence Polarization Assay in North-Western China's Hepatocellular Carcinoma Patients

Virology Journal, 2011
Background The understanding of the distribution of hepatitis B virus genotypes and the occult hepatitis B virus infection in hepatocellular carcinoma may shed light into the prevention and treatment of hepatocellular carcinoma.
Liang Ping, Wang Xiangling, Li Ding, Cheng Hong, Wu Zhiqun, Gong Weidong, Lu Jianguo, Zhang Ju   +7 more
doaj   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source