Results 131 to 140 of about 1,000,209 (254)
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Hepatocellular carcinoma (HCC) is responsible for more than 90% of primary hepatic cancer. Hepatitis C virus (HCV) infection is one of the contributing factors for HCC development. miRNAs are non‐coding RNAs and are also involved in HCV replication.
Badr Alzahrani +6 more
wiley +1 more source
JGH Open, Volume 10, Issue 4, April 2026.ABSTRACT Background Tolvaptan promotes electrolyte‐free water excretion and is widely used in Asia for ascites, but in Western countries its use is limited to hyponatremia because of hepatotoxicity concerns. Methods We performed a retrospective cohort study using the TriNetX Research Network, emulating a target trial of cirrhotic patients with ...
Kazuya Okushin +5 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 2, April 2026.ABSTRACT Herpes simplex virus Type 1 (HSV‐1) is a prevalent infectious agent globally, often causing oral infections like gingivostomatitis. The ICP0 protein of HSV‐1 exacerbates infection severity by inhibiting antiviral responses. Our study explored how combinations of CAPE (caffeic acid phenethyl ester) and acyclovir influenced immune responses in ...
Merve Sen, Sefa Celik
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau +62 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 4, April 2026.The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley +1 more source
Addiction Biology, Volume 31, Issue 4, April 2026.In patients with chronic HCV infection, mental distress was positively associated with circulating cytokines levels in non‐OMT patients, but showed the opposite pattern in patients receiving OMT. Interaction analyses confirmed that OMT modified the relationship between symptom burden and cytokines, particularly the pro‐inflammatory TNF, IL‐2, IL‐8 and ...
Kristin Nygård‐Odeh +6 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.In this research work, the cytotoxicity of eight sulfonated silver(I) and gold(I) N‐heterocyclic carbene (NHC) complexes—four newly synthesized—was evaluated against human liver cancer cells. Two compounds showed selectivity for cancer cells, inducing ROS‐dependent autophagic cell death via AKT/mTOR pathway inhibition without triggering apoptosis ...
Rocchina Miglionico +6 more
wiley +1 more source
Journal of Viral Hepatitis, Volume 33, Issue 4, April 2026.ABSTRACT Since the initial description of HDV, in the last four decades Italy has witnessed a profound decline of the infection driven by HBV vaccination, contrasted however by the reconstitution of a viral reservoir through migratory flows from endemic HDV areas; in parallel, the medical scenario has changed, resulting in different clinical outcomes ...
Gian Paolo Caviglia, Tommaso Stroffolini
wiley +1 more source
Liver International, Volume 46, Issue 4, April 2026.ABSTRACT The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention ...
Oana Săndulescu +5 more
wiley +1 more source