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Delta Hepatitis and the Hepatitis Delta Virus
1989Since its discovery in 1977 by Rizzetto and co-workers from Turin, Italy, the hepatitis delta virus (HDV) has become a focus of worldwide interest—interest almost equal to its worldwide importance.1, 2 The delta antigen, which first appeared to be a poorly explained finding of immunofluorescence staining in liver biopsies from Italian chronic hepatitis
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1989
The Hepatitis Delta Virus (HVD) occupies a unique niche in humai virology. At variance with conventional animal viruses, it cannot replicate autonomously but requires the presence of the Hepatitis B Virus (HBV) to initiate infection. It behaves like a defective interfering agent, in that it ihibits the synthesis of the competent HBV helper once its ...
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The Hepatitis Delta Virus (HVD) occupies a unique niche in humai virology. At variance with conventional animal viruses, it cannot replicate autonomously but requires the presence of the Hepatitis B Virus (HBV) to initiate infection. It behaves like a defective interfering agent, in that it ihibits the synthesis of the competent HBV helper once its ...
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Journal of Hepatology, 2003
Twenty-five years ago Rizzetto et al. [1], while examining liver biopsies from individuals infected with HBV, discovered by immunofluorescence a previously unrecognized nuclear antigen that was subsequently shown to be a specific marker of a novel human pathogen, HDV. The clinical association with HBV results from the fact that HDV is a defective virus
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Twenty-five years ago Rizzetto et al. [1], while examining liver biopsies from individuals infected with HBV, discovered by immunofluorescence a previously unrecognized nuclear antigen that was subsequently shown to be a specific marker of a novel human pathogen, HDV. The clinical association with HBV results from the fact that HDV is a defective virus
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Expert Review of Anti-infective Therapy, 2013
Hepatitis delta virus (HDV) is a defective RNA virus that depends on hepatitis B virus (HBV) for its lifecycle. Treatment of chronic HDV infection is difficult as it does not have an enzymatic function as a target, such as polymerases and proteases of HBV and hepatitis C virus.
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Hepatitis delta virus (HDV) is a defective RNA virus that depends on hepatitis B virus (HBV) for its lifecycle. Treatment of chronic HDV infection is difficult as it does not have an enzymatic function as a target, such as polymerases and proteases of HBV and hepatitis C virus.
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Seminars in Liver Disease, 2012
The hepatitis D virus (HDV) is unique in animal virology. It is the smallest of human pathogens, re- quires the HBsAg capsid of the hepatitis B virus (HBV) to assembly into infectious virions, and parasitizes the transcriptional machinery of the host. Hepatitis D is ubiquitous but prevalence varies throughout the world.
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The hepatitis D virus (HDV) is unique in animal virology. It is the smallest of human pathogens, re- quires the HBsAg capsid of the hepatitis B virus (HBV) to assembly into infectious virions, and parasitizes the transcriptional machinery of the host. Hepatitis D is ubiquitous but prevalence varies throughout the world.
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Hepatitis delta virus RNA in serum of patients with chronic delta hepatitis
Digestive Diseases and Sciences, 1994We studied 28 patients with chronic delta hepatitis for the presence of hepatitis delta virus (HDV) RNA in serum. The hot start polymerase chain reaction (PCR) method, in which the reaction begins at 60-80 degrees C, showed a higher sensitivity than conventional PCR reaction.
L H, Simpson +4 more
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Delta in Denmark: prevalence of hepatitis delta virus infection
Infectious DiseasesHepatitis delta virus (HDV) infection has an aggressive disease course and is the most difficult to treat of the human hepatitis viruses. In Denmark, as in many countries, the national prevalence of HDV has not been established. Based on diagnoses and laboratory test results in national healthcare registries, we estimated that the prevalence of current
Hugh Watson +3 more
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Treatment of Chronic Delta Hepatitis
Seminars in Liver Disease, 2012Chronic delta hepatitis (CDH) remains the most progressive form of chronic viral hepatitis and as such its successful treatment is important. However, in striking contrast to the situation in chronic hepatitis B and C, no new drugs for its treatment have been introduced in the recent past and interferons remain the only evidence-based effective ...
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Presse medicale (Paris, France : 1983), 1988
Hepatitis delta virus is a small defective RNA virus that replicates only in the presence of hepatitis B virus. Delta infections occur in two circumstances: co-infections where both viruses are acquired simultaneously, and superinfections where delta virus infects a patient who is already a chronic carrier of hepatitis B virus.
A, Goudeau, F, Dubois, P, Leturcq
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Hepatitis delta virus is a small defective RNA virus that replicates only in the presence of hepatitis B virus. Delta infections occur in two circumstances: co-infections where both viruses are acquired simultaneously, and superinfections where delta virus infects a patient who is already a chronic carrier of hepatitis B virus.
A, Goudeau, F, Dubois, P, Leturcq
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