Results 41 to 50 of about 31,107,750 (262)
Baylor University Medical Center Proceedings, 2012 Hepatitis E usually presents as a self-limiting viral hepatitis. It is not commonly seen in the United States and is more prevalent in endemic areas. Signs and symptoms are similar to those of other acute viral hepatitis infections. Here a case is presented of a man who recently returned from India and was found to have acute viral hepatitis E ...
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Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development [PDF]
, 2013 Background: Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and ...
Jörg Bojunga +127 more
core +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Community leaders’ experiences of hepatitis E in a Namibian informal settlement: A qualitative study
Journal of Public Health in AfricaBackground: The hepatitis E virus (HEV) is a major global health concern, with an estimated one-third of the human population infected. It is particularly prevalent in developing countries, especially in informal settlements where inadequate sanitation ...
Abraham V. Nghikevali, Talitha Crowley
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Molecular epidemiological study of clinical cases of acute hepatitis E in Belarus
Журнал микробиологии, эпидемиологии и иммунобиологии, 2023 Relevance. The frequency of occurrence of anamnestic antibodies to the hepatitis E virus (HEV) in the general population of the Republic of Belarus is 7.3%, which is clearly not consistent with the low incidence of hepatitis E (HE).
Vladimir V. Davydov +10 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
HEPATITIS E: А NEW PROBLEM IN TRANSPANTOLOGY?
Вестник трансплантологии и искусственных органов, 2012 Hepatitis E is enterically transmitted infection and is the cause of outbreaks and sporadic cases. Disease was originally registered only in the developing subtropical and tropical countries and has been connected with I or II genotypes of hepatitis E ...
M. L. Zubkin +6 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Transfusion Medicine and Hemotherapy, 2009 This paper was completed on June 22, 2007, and approved by the German Advisory Committee Blood (Arbeitskreis Blut) on October 1, 2007. It was compiled by the members of the subgroup ‘Assessment of Pathogens Transmissible by Blood’ of the German Advisory Committee Blood (Arbeitskreis Blut): Prof. Dr. Georg Pauli Dr. Johannes Blumel Prof.
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