Results 61 to 70 of about 19,491,478 (363)

An acute infection due to hepatitis E in the context of a patient with rituximab and methotrexate therapy

European Journal of Case Reports in Internal Medicine
Background: This report presents the influence of immunosuppression by new rheumatological therapies on hepatitis E virus infection in a 54-year-old male patient with an anti-synthetase syndrome and treatment with methotrexate and rituximab.
Francisco Josué Cordero Pérez, Eva P. Martín Garrido, Marta Antona-Herranz, Carmen Bailador-Andrés, Pilar Conde-Gacho, Clara de Diego-Cobos, Santiago J. Rodriguez-Gomez   +6 more
doaj   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Community leaders’ experiences of hepatitis E in a Namibian informal settlement: A qualitative study

Journal of Public Health in Africa
Background: The hepatitis E virus (HEV) is a major global health concern, with an estimated one-third of the human population infected. It is particularly prevalent in developing countries, especially in informal settlements where inadequate sanitation ...
Abraham V. Nghikevali, Talitha Crowley
doaj   +1 more source

An Atypical Presentation of Hepatitis E in Pregnancy

Medicine Science, 2016
Hepatitis E is water born disease and transmitted by feco-oral route and it is an emerging infectious agent causing acute viral hepatitis all over the world. During pregnancy, especially in the third trimester, hepatitis E infection is characterized by a
Debkalyan Maji, Madhusudan Dey, Monica Saraswat, Manash Biswas   +3 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Atomic‐Level Engineering of Synthetic Receptors for Enhanced Virus Detection and Removal

Advanced Healthcare Materials, EarlyView.
Advanced computational techniques are employed to design and optimize computationally designed imprinted receptors (CIRs) for virus detection and removal. CIR‐conjugated piezoelectric sensor achieves highly sensitive virus detection in water and human serum. CIR‐integrated membranes remove 100% of pathogenic viruses from contaminated water.
Eda Akin, Ekin Sehit, Nastasia Sanda Moldovean‐Cioroianu, Sahana Tavaragondi, Sophia Slenczka, Roderich Süssmuth, Friedrich Jurk, Manuel van Gemmeren, Zeynep Altintas   +8 more
wiley   +1 more source

Transfusion-transmitted hepatitis E

Zhongguo shuxue zazhi
Hepatitis E is an acute and self-limiting viral hepatitis caused by the hepatitis E virus (HEV). It has a higher mortality rate among immunosuppressed patients and pregnant women infected with HEV.
LI Baixun, LIU Tianxu, HUANG Liqin, DANG Yingnan, WANG Lin   +4 more
doaj   +1 more source

Epidemiology, diagnosis, vaccines, and bibliometric analysis of the 100 top-cited studies on Hepatitis E virus

Human Vaccines & Immunotherapeutics, 2021
Introduction In low-income countries, Hepatitis E infection is a common cause of acute hepatitis. So far, only two recombinant vaccines (rHEV and HEV 239) have been developed against Hepatitis E virus (HEV).
Tauseef Ahmad, Saima Nasir, Taha Hussein Musa, Saif Aldeen S AlRyalat, Muhammad Khan, Jin Hui   +5 more
doaj   +1 more source