Results 201 to 210 of about 24,189 (241)
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Dysplastic nodules and hepatocarcinogenesis
Clinics in Liver Disease, 2002In the last decade, careful examination of explanted cirrhotic livers in liver transplant centers around the world has confirmed the findings of the earlier Japanese investigators: DNs (by this or any other name) represent hepatic, premalignant lesions in chronic liver disease.
Neil D, Theise +2 more
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Chromosomal proteins in hepatocarcinogenesis
Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1978The chromosomal proteins of rat liver were studied by SDS-gel electrophoresis during the process of nitrosomorpholine-induced hepatocarcinogenesis, in the primary hepatomas thus obtained, and in their metastases. It was found that an increased proteolytic activity was present in liver homogenates from carcinogen-fed animals which caused differences ...
R, Tsanev, D, Hadjiolov
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Ectopic liver and hepatocarcinogenesis
European Journal of Gastroenterology & Hepatology, 2004Hepatocellular carcinomata are relatively rare in the western hemisphere, but they are much more common in South-East Asia and sub-Saharan Africa due to high endogenous levels of hepatitis B and C. Ectopic liver tissue usually is found incidentally (frequently at cholecystectomy), but it may also be found due to neoplastic changes or compressive ...
Christine P J, Caygill +1 more
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Role of pesticides in hepatocarcinogenesis
Journal of Toxicology and Environmental Health, 1979Pesticides are biologically active substances that are significant environmental contaminants. Only a few of the many pesticides have been subjected to short- or long-term carcinogenicity tests. To date, 16 of them have been identified as hepatocarcinogenic agents in animals, usually mice.
J, Sugár +4 more
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Choline and Hepatocarcinogenesis in the Rat
1995Rats fed a choline deficient diet develop foci of enzyme-altered hepatocytes with subsequent formation of hepatic tumors. This is the only nutritional deficiency that, in itself, causes cancer. We suggested that carcinogenesis is triggered, in part, because of abnormalities in cell signals which regulate cell proliferation and cell death.
S H, Zeisel +3 more
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Hepatocarcinogenesis in rodents and humans
Journal of Cancer Research and Clinical Oncology, 1995In hepatocarcinogenesis in rodents, induction of foci and nodules comprising clonally proliferated initiated cells is considered to be essential for the future development of carcinomas. Nodules in human cirrhotic liver, though known to be associated with a high hepatocellular carcinoma risk, have generally been regarded as regenerative in nature, and ...
T, Kitagawa +4 more
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Human and Experimental Hepatocarcinogenesis
Scandinavian Journal of Gastroenterology, 1998Human liver cancer is increasing worldwide, including in Hungary. The detection of liver tumors in premalignant or early malignant states is essential for successful treatment. MC-29 virus-induced chicken hepatoma and rodent, fish and monkey models for chemical hepatocarcinogenesis were studied and compared to humans.
Z, Schaff +5 more
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Mechanisms of Human Hepatocarcinogenesis
Current Molecular Medicine, 2003The major risk factors and etiological agents responsible for development of hepatocellular carcinoma in humans have been identified and characterized. Among these are chronic infection with hepatitis B virus or hepatitis C virus, exposure to aflatoxin B1, and cirrhosis of any etiology (including alcoholic cirrhosis and cirrhosis associated with ...
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Initiation and promotion in hepatocarcinogenesis
Archives of Toxicology, 1987Initiation and promotion have been recognized as essential parts of the multi-stage concept of chemical carcinogenesis. In the liver, initiation by genotoxic carcinogens results in appearance of foci of phenotypically altered hepatocytes. Accelerated growth and phenotypic changes of these foci during tumor promotion by phenobarbital are described, and ...
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Molecular mechanism of hepatocarcinogenesis
Journal of Gastroenterology and Hepatology, 1997ABSTRACTTo clarify the relative role of hepatitis C virus (HCV) and hepatitis B virus (HBV) in hepatocarcinogenesis in hepatitis B surface antigen (HBsAg)‐negative hepatocellular carcinoma (HCC) in Taiwan, polymerase chain reaction (PCR) was used to detect the HCV‐RNA and HBV‐DNA sequences in the serum and liver tissues from 31 HBsAg‐negative HCC ...
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