Results 1 to 10 of about 12,555 (220)

Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats

Molecules, 2021
This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats.
Rawiwan Wongpoomchai, Kanokwan Jarukamjorn, Arpamas Vachiraarunwong   +2 more
exaly   +4 more sources

Long-Term Exposure to Microplastics Promotes Early-Stage Hepatocarcinogenesis Induced by Diethylnitrosamine in Rats by Modulation of Their Gut Microbiota [PDF]

Toxics
Hepatocarcinogenesis is linked to environmental factors, with microplastics (MPs) emerging as a global environmental concern that may contribute to liver injury.
Huina Guo, Jianan Wang, Shaowen Huang, Suren Rao Sooranna, Fangyi Shu, Genliang Li   +5 more
doaj   +2 more sources

Inflammation-Driven Downregulation of CYP2E1 Is Associated with Attenuated Diethylnitrosamine (DEN)-Induced Hepatocarcinogenesis [PDF]

Cells
Inflammation is widely viewed as a driver of hepatocellular carcinoma (HCC), yet inflammatory signaling also reshapes hepatic xenobiotic metabolism. Here, we established transgenic (Tg) IKKβΔhep mice (Tg-IKKβΔhep), which combine hepatocyte-specific IKKβ ...
Yoshihiro Tsuchiya, Yusuke Sotomaru, Akinori Kanai, Shin Maeda, Hideaki Kamata   +4 more
doaj   +2 more sources

Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats

Molecular Medicine Reports, 2020
An overwhelming endoplasmic reticulum stress (ERS) and the following unfolded protein response (UPR) can induce hepatic inflammation, fibrosis and hepatocellular carcinoma (HCC). Caudatin, one of the species of C‑21 steroidal glycosides mainly isolated from the roots of Cynanchum bungei Decne, exhibits potent anticancer activities in vivo. However, the
Song, Jie, Ding, Wenbo, Liu, Bojia, Liu, Dan, Xia, Zhi, Zhang, Li, Cui, Li, Luo, Yi, Jia, Xiaobin, Feng, Liang   +9 more
openaire   +4 more sources

The potential chemo preventive effect of ursolic acid isolated from Paulownia tomentosa, against N-diethylnitrosamine: initiated and promoted hepatocarcinogenesis

Heliyon, 2019
The present study discusses the isolation of ursolic acid from the chloroform extract of Paulownia tomentosa (Thunb) Steud fruits and its cytotoxic effect has been assessed in-vitro was performed in different cells lines (A-549, MCF-7, HepG2) and in-vivo
Sanaa A. Ali, Nabaweya A. Ibrahim, Magdy M.D. Mohammed, Seham El-Hawary, Esraa A. Refaat   +4 more
doaj   +2 more sources

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse

BMC Cancer, 2018
Background Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with modest tumor development in the ...
Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky, Kornélia Baghy   +3 more
doaj   +2 more sources

Dynamics of Postmortem Gene Expression in Normal and Neoplastic Murine Liver [PDF]

Life
The use of postmortem (autopsy) material in fundamental and applied biomedical research significantly facilitates the collection of biomaterial for statistically robust sample cohorts.
Evgeny E. Buyko, Ekaterina A. Perina, Danil S. Sobakin, Matvey M. Tsyganov, Dmitry V. Vasilchenko, Sergey V. Vtorushin, Alexander A. Ufandeev, Elena B. Diksas, Olga A. Kaidash, Ekaterina S. Hmelevskaya, Ekaterina V. Parochkina, Igor A. Popov, Vladimir V. Ivanov, Stanislav I. Pekov, Elena V. Udut   +14 more
doaj   +2 more sources

Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats

Tumor Biology, 2017
Hepatocellular carcinoma is one of the most common cancers, and approximately 80% develop from cirrhotic livers. We have previously shown that the aspartate salt of adenosine prevents and reverses carbon tetrachloride–induced liver fibrosis in rats ...
Gabriela Velasco-Loyden, Lidia Pérez-Martínez, Susana Vidrio-Gómez, Julio Isael Pérez-Carreón, Victoria Chagoya de Sánchez   +4 more
doaj   +2 more sources

Characterization and ameliorative effects of Chenopodium murale hydroethanolic extract against diethylnitrosamine-induced hepato-renal damage and malfunction

Journal of the Arab Society for Medical Research, 2023
Background/aim Chenopodium genus has broad applications in folk medicine. Chenopodium murale (C. murale) exhibited several pharmacological benefits, including hypotensive, anti-inflammatory, analgesic, antifungal, antibacterial, phytotoxic ...
Howida S. Abou- Seif, Osama M. Ahmed, Samah A. El-Newary, Marwa E. Shabana, Mahitab I. EL-Kassaby, Ghada M. Elqattan, Hussein G. Sawie   +6 more
doaj   +1 more source

Inhibitory Effect of Thai Purple Rice Husk Extract on Chemically Induced Carcinogenesis in Rats

Molecules, 2021
This study investigated the cancer chemopreventive effects of an acidic methanol extract of purple rice husk on chemically induced carcinogenesis in rats. This purple rice husk extract (PRHE) had high polyphenol contents.
Charatda Punvittayagul, Arpamas Chariyakornkul, Paweena Sankam, Rawiwan Wongpoomchai   +3 more
doaj   +1 more source