Results 11 to 20 of about 12,555 (220)

Combining Crocin and Sorafenib Improves Their Tumor-Inhibiting Effects in a Rat Model of Diethylnitrosamine-Induced Cirrhotic-Hepatocellular Carcinoma

Cancers, 2023
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths.
B. Awad, A. Hamza, Amna Al-Maktoum, S. Al-Salam, A. Amin   +4 more
semanticscholar   +1 more source

6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity

Mediators of Inflammation, 2021
Diethylnitrosamine (DEN) is a well‐known hepatocarcinogen, and its oral administration causes severe liver damage including cancer. DEN induces the pathogenesis of the liver through reactive oxygen species mediated inflammation and modulation of various ...
M. Alsahli, S. Almatroodi, A. Almatroudi, A. Khan, S. Anwar, Abdulmajeed G. Almutary, Faris A Alrumaihi, A. Rahmani   +7 more
semanticscholar   +1 more source

Chemopreventive Effect of Cratoxylum formosum (Jack) ssp. pruniflorum on Initial Stage Hepatocarcinogenesis in Rats

Molecules, 2021
Cratoxylum formosum ssp. pruniflorum (Kurz) Gogelein (CP) is an indigenous plant found mainly in southeast Asia. Several in vitro studies have confirmed its activity against hepatocellular carcinoma; however, in vivo studies of the effect of CP on liver ...
Piman Pocasap, Natthida Weerapreeyakul, Rawiwan Wongpoomchai   +2 more
doaj   +1 more source

Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine

Scientific Reports, 2022
Several fractions of Calotropis gigantea extracts have been proposed to have potential anticancer activity in many cancer models. The present study evaluated the anticancer activity of C.
Suphunwadee Sawong, Dumrongsak Pekthong, Pennapha Suknoppakit, Thanwarat Winitchaikul, Worasak Kaewkong, J. Somran, Chaidan Intapa, Supawadee Parhira, Piyarat Srisawang   +8 more
semanticscholar   +1 more source

Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
Liver cancer is a critical clinical condition with augmented malignancy, rapid progression, and poor prognosis. Liver cancer often initiates as fibrosis, develops as cirrhosis, and results in cancer. For centuries, medicinal plants have been incorporated
Yulai You, Fengfeng Zhu, Zhenhua Li, Lingfeng Zhang, Yu Xie, A. Chinnathambi, T. Alahmadi, Bei Lu   +7 more
semanticscholar   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It was suggested that albendazole (ABZ) is a powerful inhibitor of several carcinoma types. However, the bioavailability of ABZ is very poor.
S. Saber, M. Nasr, A. Saad, A. Mourad, N. Gobba, A. Shata, Abdel-Moneim Hafez, Ramy N. Elsergany, Heba El-agamy, E. El-Ahwany, Noha A. Amin, S. Girgis, Yaser H A Elewa, M. Mahmoud, G. Batiha, Magdy Abou El-Rous, Islam M Kamal, Mohamed M. Y. Kaddah, Ahmed E. Khodir   +18 more
semanticscholar   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Piperlongumine inhibits diethylnitrosamine induced hepatocellular carcinoma in rats

Human and Experimental Toxicology, 2022
Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Piperlongumine (PL) has been claimed to have cytotoxic and HCC inhibitory effects in various cancer cell lines and xenograft models, but the ...
Ashish Kumar, Manisha Naithani, Nitesh Kumar, N. Singh, S. Agrawal, Ambika Sharma, Surabhi Thapliyal, Jagjit Singh, S. Handu   +8 more
semanticscholar   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source