Results 41 to 50 of about 12,555 (220)

Organ toxicity of diethylnitrosamine and capsaicin in mice – in vivo study

Annales Universitatis Paedagogicae Cracoviensis Studia Naturae, 2018
Diethylnitrosamine (DEN) is proven to be toxic to kidneys and liver and to act as a potent carcinogen mainly in liver. Capsaicin (CAP) is an alkaloid produced by Capsicum genus plants and is considered to be a protective agent against toxicity and ...
Vendula Kuchařová, Ondřej Daněk , Miša Škorič, Ivana Veselá, Jaroslava Tomenendálová   +4 more
doaj   +1 more source

Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries

Pharmaceuticals, 2023
According to population-based studies, lung cancer is the prominent reason for cancer-related mortality worldwide in males and is also rising in females at an alarming rate. Sorafenib (SOR), which is approved for the treatment of hepatocellular carcinoma
Betul Cicek, Ahmet Hacimuftuoglu, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Serhat Hayme, Dimitris Matthaios, Dimitra P. Vageli, Sotirios G. Doukas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi   +15 more
doaj   +1 more source

Newcastle and Doxorubicin attenuated against diethylnitrosoamine as anti-proliferative and immunosuppresor effects which induced hepatocellular carcinoma [PDF]

Benha Veterinary Medical Journal, 2021
Doxorubicin is a broad spectrum antitumor antibiotic. Newcastle disease virus (NDV ) is one such virus with an inherent oncolytic property. This study was done to investigate the antitumor effects of Doxorubicin and NDV on Diethylnitrosamine (DEN ...
mahmoud elashrey, Kamel Zyan, Afaf Desoky   +2 more
doaj   +1 more source

Newcastle and Doxorubicin attenuated against diethylnitrosoamine as antitumor effects which induced hepatocellular carcinoma [PDF]

Benha Veterinary Medical Journal, 2021
Doxorubicin is a broad spectrum antitumor antibiotic. Newcastle disease virus (NDV ) is one such virus with an inherent oncolytic property. This study was done to investigate the antitumor effects of Doxorubicin and NDV on Diethylnitrosamine (DEN ...
mahmoud elashrey, Kamel Zyan, Afaf Desoky   +2 more
doaj   +1 more source

Disruption of Growth Hormone Receptor Signaling Abrogates Hepatocellular Carcinoma Development

Journal of Hepatocellular Carcinoma, 2022
Abedul Haque,1 Vishal Sahu,1 Jamie Lynne Lombardo,2 Lianchun Xiao,3 Bhawana George,1 Robert A Wolff,4 Jeffrey S Morris,3 Asif Rashid,2 John J Kopchick,5,6 Ahmed O Kaseb,4 Hesham M Amin1,7 1Department of Hematopathology, The University of Texas MD ...
Haque A, Sahu V, Lombardo JL, Xiao L, George B, Wolff RA, Morris JS, Rashid A, Kopchick JJ, Kaseb AO, Amin HM   +10 more
doaj  

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract

Asian Pacific Journal of Cancer Prevention, 2019
Background: Diethylnitrosamine (DENA), a well-known dietary carcinogen, related to cancer initiation of various organs. The present study investigated the deleterious mechanisms involved in the early destructive changes of DENA in different organs namely,
Dina F Mansour, H. Abdallah, Bassant M. M. Ibrahim, Rehab R. Hegazy, Reham S. E. Esmail, Lubna O. Abdel-Salam   +5 more
semanticscholar   +1 more source

Ellagic acid could prevent experimentally induced oxidative stress in rats [PDF]

Eurasian Journal of Veterinary Sciences, 2022
Aim: Reactive oxygen species (ROS) are produced during the metabolism of diethylnitrosamine (DEN) and phenobarbital (PB). Ellagic acid (EA) is a natural biologically active polyphenol with antioxidant activity.
Mehmet Ali Kisacam, Gonca Ozan Kocamuftuoglu, Enver Ozan, Sema Temizer Ozan   +3 more
doaj  

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma. [PDF]

Mol Oncol
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Goikoetxea-Usandizaga N, Martinez-Chantar ML, Conter C.   +2 more
europepmc   +2 more sources

Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

Toxicology Reports, 2021
Introduction: Inflammation and oxidative stress are the main factors ascribed with interruption in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well recognized in animals and humans.
Deepika Singh, Deepak Chaudhary, Vikas Kumar, Amita Verma   +3 more
doaj   +1 more source

Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats

Experimental and Therapeutic Medicine, 2011
In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes.
Ryo, Abe, Jun-Ichi, Okano, Ryu, Imamoto, Yuki, Fujise, Yoshikazu, Murawaki   +4 more
openaire   +3 more sources