Results 41 to 50 of about 2,632 (156)

Effects of Diethylnitrosamine on Lung Neuroendocrine Cells

Experimental Lung Research, 1982
Diethylnitrosamine is known to cause squamous cell carcinoma and adenocarcinoma of the lung in Syrian golden hamsters. Sections of lungs obtained from hamsters treated with the systemic carcinogen diethylnitrosamine revealed a significant increase in the number of argyrophilic cells of neuroepithelial bodies.
openaire   +2 more sources

Long-Term Exposure to Microplastics Promotes Early-Stage Hepatocarcinogenesis Induced by Diethylnitrosamine in Rats by Modulation of Their Gut Microbiota

Toxics
Hepatocarcinogenesis is linked to environmental factors, with microplastics (MPs) emerging as a global environmental concern that may contribute to liver injury.
Huina Guo, Jianan Wang, Shaowen Huang, Suren Rao Sooranna, Fangyi Shu, Genliang Li   +5 more
doaj   +1 more source

Sequential analysis of diethylnitrosamine-induced hepatocarcinogenesis in rats

Experimental and Therapeutic Medicine, 2011
In the present study, we examined the sequential changes of diethylnitrosamine (DEN)-induced hepatocarcinogenesis in Wistar rats. After 14 weeks of DEN treatment, hyperplastic nodules developed as a consequence of the appearance of renewed hepatocytes, degenerated hepatocytes, oval cells and fibrotic changes.
Ryo, Abe, Jun-Ichi, Okano, Ryu, Imamoto, Yuki, Fujise, Yoshikazu, Murawaki   +4 more
openaire   +3 more sources

The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice [PDF]

, 2007
Dissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target.
Iancu, Cristina M., Albini, Adriana, Bachmeier, Beatrice E., Dell'Eva, Raffaella, Cilli, Michele, Vene, Roberta, Jochum, Marianne, Pfeffer, Ulrich, Schleicher, Erwin, Nerlich, Andreas G.   +9 more
core   +1 more source

Effect of Diethylnitrosamine on Monoamine Oxidase in Rat Liver

Japanese Journal of Pharmacology, 1989
The effect of diethylnitrosamine (DEN), a well-known experimental carcinogen, toward MAO-A and MAO-B activity of rat liver was investigated. The oxidations of both beta-PEA (MAO-B) and 5-HT (MAO-A) were inhibited by DEN. The K1 values of DEN in the inhibition of rat liver MAO-A and MAO-B activity were determined.
OBATA, Toshio, YAMASHITA, Hiroto, EGASHIRA, Toru, YAMANAKA, Yasumitsu   +3 more
openaire   +2 more sources

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management

Frontiers in Pharmacology
AimsDipeptidyl peptidase-4 enzyme (DPP-4) was reported to be associated with immune stimulation, resistance to anti-neoplastic agents and lipid accumulation.
Hebatollah E. Eitah, Rabab H. Sayed, Rabab H. Sayed, Yousreya A. Maklad, Amina A. Gamal el Din, Khaled Mahmoud, Ayman E. El-Sahar, Amani Alhejely, Amal A. Abdulbaqi, Hanan Naeim Attia   +9 more
doaj   +1 more source

Palladium Complex-Loaded Magnetite Nanoparticles as Drug Delivery Systems for Targeted Liver Cancer Therapy

Pharmaceutics
Background/Objectives: Liver cancer is considered one of the most dangerous types of cancer due to both the patients’ and the physician’s delay in diagnosis. Metal/ligand complexes represent antitumor drugs; however, they have several limitations such as
Sara A. M. El-Sayed, Ghadha Ibrahim Fouad, Hanan H. Beherei, Mohamed R. Shehata, Mostafa Mabrouk   +4 more
doaj   +1 more source

Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model [PDF]

, 2009
Background Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggressiveness. To explore the key genes
Zhang Jian-Ping, Jin Zhu, Guan Xiao-Hong, Zha Bin-Shan, Jian-Ping Zhang, Bin-Shan Zha, Zhang Hui-Lin, Xiao-Jing Zhu, Feng Zhen-Qing, Hui-Lin Zhang, Yue-Fang Liu, Zhu Xiao-Jing, Xiao-Hong Guan, Yu-Hua Li, Zhu Jin, Li Yu-Hua, Liu Yue-Fang, Zhen-Qing Feng   +17 more
core   +1 more source

Genotoxic and Anti-Genotoxic Assessments of Fermented Houttuynia cordata Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Colon and Liver in Rats

Foods
The incidence of multiple-organ cancers has recently increased due to simultaneous exposure to various environmental carcinogens. Houttuynia cordata Thunb. (H. cordata) is recognized for its many health benefits, including its anti-cancer properties. The
Chonikarn Singai, Pornsiri Pitchakarn, Sirinya Taya, Rawiwan Wongpoomchai, Ariyaphong Wongnoppavich   +4 more
doaj   +1 more source

Evaluation the efficacy of Leea indica leaves aqueous extract against nephrotoxicity induced by Diethylnitrosamine (DEN) in male rats

Journal of Kerbala for Agricultural Sciences, 2023
The aim of this study is to find out the quality of the aqueous extract of leea indica leaves in protecting kidney tissues from oxidative stress caused by DEN.
Mustafa Abd-Alhussein Kazam, Heba A. Abd-Alsalam Alsalame   +1 more
doaj   +1 more source