Results 61 to 70 of about 12,555 (220)

Effect of Diethylnitrosamine on Monoamine Oxidase in Rat Liver

Japanese Journal of Pharmacology, 1989
The effect of diethylnitrosamine (DEN), a well-known experimental carcinogen, toward MAO-A and MAO-B activity of rat liver was investigated. The oxidations of both beta-PEA (MAO-B) and 5-HT (MAO-A) were inhibited by DEN. The K1 values of DEN in the inhibition of rat liver MAO-A and MAO-B activity were determined.
OBATA, Toshio, YAMASHITA, Hiroto, EGASHIRA, Toru, YAMANAKA, Yasumitsu   +3 more
openaire   +2 more sources

Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice

PLoS ONE, 2019
Researchers investigating cancer chemotherapy and management continue to search for agents that selectively kill malignant cells and leave healthy neighboring cells intact.
S. A. Gani, S. Muhammad, Aminu Umar Kura, Farahnaz Barahuie, M. Hussein, S. Fakurazi   +5 more
semanticscholar   +1 more source

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management

Frontiers in Pharmacology
AimsDipeptidyl peptidase-4 enzyme (DPP-4) was reported to be associated with immune stimulation, resistance to anti-neoplastic agents and lipid accumulation.
Hebatollah E. Eitah, Rabab H. Sayed, Rabab H. Sayed, Yousreya A. Maklad, Amina A. Gamal el Din, Khaled Mahmoud, Ayman E. El-Sahar, Amani Alhejely, Amal A. Abdulbaqi, Hanan Naeim Attia   +9 more
doaj   +1 more source

Palladium Complex-Loaded Magnetite Nanoparticles as Drug Delivery Systems for Targeted Liver Cancer Therapy

Pharmaceutics
Background/Objectives: Liver cancer is considered one of the most dangerous types of cancer due to both the patients’ and the physician’s delay in diagnosis. Metal/ligand complexes represent antitumor drugs; however, they have several limitations such as
Sara A. M. El-Sayed, Ghadha Ibrahim Fouad, Hanan H. Beherei, Mohamed R. Shehata, Mostafa Mabrouk   +4 more
doaj   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, Volume 13, Issue 43, 3 August 2026.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Leveraging single‐cell RNA‐seq for uncovering naïve B cells associated with better prognosis of hepatocellular carcinoma

MedComm
Hepatocellular carcinoma (HCC) is a typical highly heterogeneous solid tumor with high morbidity and mortality worldwide, especially in China; however, the immune microenvironment of HCC has not been clarified so far.
Qingjia Sun, Rui Gao, Yingxin Lin, Xianchao Zhou, Tao Wang, Jian He   +5 more
doaj   +1 more source

Biochemical Evidence for the Antitumor Potential of Garcinia mangostana Linn. On Diethylnitrosamine-Induced Hepatic Carcinoma

Pharmacognosy Magazine, 2018
Background: Garcinia mangostana is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. Objective: The objective of this study was to elucidate the underlying biochemical protective mechanism of G. Mangostana Linn.
M. Jainu, V. Priya, S. Mohan
semanticscholar   +1 more source

Rupatadine Ameliorates Cisplatin‐Induced Hepatotoxicity in Rats: Targeting HMGB1/TLR4/NF‐κB and NLRP3/Caspase‐1 Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Graphical representation of the probable mechanisms underlying the effect of RUPA on CISP‐evoked hepatotoxicity in rats. ABSTRACT Despite cisplatin (CISP) is broadly employed in cancer therapy, its adverse effects, involving hepatotoxicity, restrict its clinical usage.
Shaimaa Mohamed Abdelrahman, Amany Abdlrehim Bekhit, Olivia N. Beshay   +2 more
wiley   +1 more source