Results 81 to 90 of about 12,555 (220)

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice

Tumor Biology, 2017
Previous in vitro studies have demonstrated that miR-144 inhibits hepatocellular carcinoma cell proliferation, invasion, and migration. We have shown that miR-144, injected intravenously, is taken up by the liver and induces endogenous hepatic synthesis ...
Quan He, Fangfei Wang, Takashi Honda, Diana M Lindquist, Jonathan R Dillman, Nikolai A Timchenko, Andrew N Redington   +6 more
doaj   +1 more source

Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats

Asian Journal of Pharmaceutical Sciences, 2017
Graphical Abstract The present study was conducted to decipher the role of 0.5 ml Hesperetin conjugated gold nanoparticles (Au-mPEG(5000)-S-HP NPs) during diethylnitrosamine (DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the ...
G. Krishnan, Jayakumar Subramaniyan, Pramila Chengalvarayan Subramani, B. Muralidharan, Devaki Thiruvengadam   +4 more
semanticscholar   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, Volume 9, Issue 3, Page 546-557, March 2026.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Genotoxic and Anti-Genotoxic Assessments of Fermented Houttuynia cordata Thunb. Leaf Ethanolic Extract and Its Anti-Cancer Effect in a Dual-Organ Carcinogenesis Model of Colon and Liver in Rats

Foods
The incidence of multiple-organ cancers has recently increased due to simultaneous exposure to various environmental carcinogens. Houttuynia cordata Thunb. (H. cordata) is recognized for its many health benefits, including its anti-cancer properties. The
Chonikarn Singai, Pornsiri Pitchakarn, Sirinya Taya, Rawiwan Wongpoomchai, Ariyaphong Wongnoppavich   +4 more
doaj   +1 more source

Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances

Scientific Reports, 2017
Chronic alcohol consumption increases the risk of hepatocellular carcinoma (HCC). However, little is known about the potential immunological mechanisms by which ethanol affects tumor progression.
Guoxiu Yan, Xuefu Wang, Cheng-song Sun, Xiaodong Zheng, Haiming Wei, Z. Tian, R. Sun   +6 more
semanticscholar   +1 more source

Gamma-irradiated β-glucan modulates signaling molecular targets of hepatocellular carcinoma in rats

Tumor Biology, 2017
β-glucans are one of the most abundant forms of polysaccharides known as biological response modifiers which influence host’s biological response and stimulate immune system.
Sawsan M Elsonbaty, Walid E Zahran, Fatma SM Moawed   +2 more
doaj   +1 more source

Morphine does no promote esophageal carcinogenesis in rats exposed to diethylnitrosamine Morfina não promove carcinogênese esofágica em ratos expostos à dietilnitrosamina

Arquivos de Gastroenterologia, 2008
BACKGROUND: The high incidence of esophageal cancer in the north of Iran has been associated to the consumption of opium and exposure to nitrosamines. Diethylnitrosamine has an established potential of producing experimental cancer in the esophagus and ...
Carlos Frota Dillenburg, Cleber Dario Pinto Kruel, Carlos Thadeu Cerski, Maria Isabel Edelweiss, Tiago Luís Dedavid e Silva, André Silvio Schier   +5 more
doaj   +1 more source

Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats

Biochemistry and Biophysics Reports, 2020
Liver damage involves oxidative stress and a progression from chronic hepatitis to hepatocellular carcinoma (HCC). The increased incidence of liver disease in Egypt and other countries in the last decade, coupled with poor prognosis, justify the critical
Nihad M. Abdel-Monem, Mohammad A. El-Saadani, Ayman S. Daba, Samar R. Saleh, Eiman Aleem   +4 more
doaj   +1 more source

Evaluation of the antitumor activity of platinum nanoparticles in the treatment of hepatocellular carcinoma induced in rats

Tumor Biology, 2017
This study aimed to evaluate the antitumor activity of platinum nanoparticles compared with cis -platin both in vitro and in vivo in the treatment of hepatocellular carcinoma induced in rats. The treatment efficacy of platinum nanoparticles was evaluated
Amina Medhat, Somaya Mansour, Sawsan El-sonbaty, Eman Kandil, Mustafa Mahmoud   +4 more
doaj   +1 more source