Results 101 to 110 of about 2,632 (156)

Carcinogenesis in different animal species by diethylnitrosamine

Experientia, 1967
Die hepato-cancerogene Wirkung von Diathylnitrosamin konnte an 11 verschiedenen Tierarten in chronisch-toxikologischen Untersuchungen nachgewiesen werden. Die zur Krebserzeugung benotigten Gesamtdosen liegen bei allen Tierarten in der gleichen Grossenordnung.
D, Schmähl, H, Osswald
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Carcinogenicity of diethylnitrosamine in vitamin‐A‐deficient mice

International Journal of Cancer, 1987
AbstractThe effect of suboptimal levels of dietary vitamin A on diethylnitrosamine (DEN) carcinogenesis was studied in BALB/c and Swiss mice. Two different dietary regimens were employed to induce vitamin A deficiency and DEN was administered by gavage at 2 dose levels: 0.6 mg/kg as a single dose and 200 mg/kg in 4 divided doses.
U, Santhanam, V S, Lalitha, S V, Bhide
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Effect of diazepam on microsomal diethylnitrosamine metabolism in gerbils

Journal of Cancer Research and Clinical Oncology, 1982
Dealkylation of diethylnitrosamine (DEN) by a liver microsomal fraction was measured after treatment of the Mongolian gerbil with DEN, Valium, or DEN plus Valium. Valium-dosed male and female animals showed strongly stimulated deethylase levels compared with the controls. This was also true of the DEN-treated females.
P, Conradt, U, Green
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Effects of butylated hydroxytoluene alone or with diethylnitrosamine in mice

Food and Cosmetics Toxicology, 1974
Abstract Mice (18 months old) given butylated hydroxytoluene (BHT) at a dietary level of 0·75% for 16 months had 63·6% of lung tumours compared with 24·0% in controls. Mice given dietary BHT as well as diethylnitrosamine (DENA) in the drinking-water (average total intake 330 mg DENA/kg) had more lung tumours per mouse (4·0) than did the controls or ...
N K, Clapp, R L, Tyndall, R B, Cumming, J A, Otten   +3 more
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Carcinomas of the esophagus in rats ingesting diethylnitrosamine

European Journal of Cancer (1965), 1975
Abstract Buffalo strain male and female rats 12 weeks of age ingested 0·0114% diethylnitrosamine (DEN) in the diet for 26 weeks and were returned to the basal diet without DEN for the remainder of the experiment. Rats survived an average of 28 weeks.
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Temporal Advancement of Diethylnitrosamine Carcinogenesis in Aging Mice

Journal of Gerontology, 1981
Female BALB/c mice were given diethylnitrosamine (DEN) in their drinking water beginning at 2.5, 9.5, and 17 months of age (cumulative dose approximately 300 to 400 mg/kg body weight) or were untreated. Median times of death for the treatment groups were 193, 168, and 125 days, respectively, after cessation of DEN treatment and were significantly ...
Clapp, N K, Perkins, E H, Klima, W C, Cacheiro, L H   +3 more
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Inactivation of tissue-specific inhibitors by a carcinogen (diethylnitrosamine)

Experientia, 1969
Der Einbau von Thymidin in Leberexplantate wird durch losliche Leberproteine gehemmt. Diese Hemmung ist aufgehoben, wenn die Proteine aus Lebern karzinogenbehandelter Tiere prapariert wurden. Dieser Effekt ist organspezifisch.
M, Volm, V, Kinzel, U, Mohr, R, Süss
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Ferritin is increased in diethylnitrosamine - altered rat hepatocytes

Biochemical and Biophysical Research Communications, 1981
Abstract Ferritin was localized by immunoperoxidase in rat liver during the early stages of experimental carcinogenesis induced by diethylnitrosamine. Carcinogen - altered hepatocytes, indentified by their reduction in membrane-bound ATPase activity, showed a highly elevated content in ferritin (or ferritin subunits), compared to normal hepatocytes ...
C, Beaumont, E, Le Rumeur, C, Guillouzo, M F, Latinier, M, Bourel, A, Guillouzo   +5 more
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Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus

Journal of Cellular Biochemistry, 1994
AbstractA series of 16 experiments, using a total of 2,000 BD6 rats, was designed in order to assess the ability of 8 individual agents or their combinations to modulate the liver and oesophageal carcinogenesis induced by multiple doses of diethylnitrosamine (DEN).
R. M. Balansky, P. M. Blagoeva, Z. I. Mircheva, DE FLORA, SILVIO   +3 more
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Diethylnitrosamine Induction of Hepatocarcinogenesis in Mice

Diethylnitrosamine (DEN) is a chemical hepatocarcinogenic agent that triggers a large array of oncogenic mutations after a single injection. Initiated hepatocytes subsequently undergo clonal expansion within a proliferative environment, rendering the DEN model a comprehensive carcinogen.
Jules, Sotty, Pierre, Bablon, Paul-Henry, Weiss, Patrick, Soussan   +3 more
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