Results 71 to 80 of about 12,555 (220)

Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats

Biological Research, 2010
Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the ...
KANNAMPALLI PRADEEP, CHANDRASEKARAN VICTOR RAJ MOHAN, KUPANNAN GOBIANAND, SIVANESAN KARTHIKEYAN   +3 more
doaj  

Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018
OBJECTIVE Hepatic cancer is well known, and leading cancer around the world and remain asymptomatic diseases. Carissa carandas possess anti-proliferative, antioxidant, hepatoprotective property and used in hepatic cancer.
Deepika Singh, Manvendra Singh, Ekta Yadav, N. Falls, Deependra Singh Dangi, Vikas Kumar, P. Ramteke, A. Verma   +7 more
semanticscholar   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B.

Toxicology Letters, 2018
Hepatocellular carcinoma (HCC) is a major global health problem. Therapeutic interventions of HCC are still limited because of its complicated molecular pathogenesis.
S. Saber, Amr A. A. Mahmoud, Reham M Goda, Noha S Helal, E. El-Ahwany, Rasha H. Abdelghany   +5 more
semanticscholar   +1 more source

Multi‐omics insights for deciphering prognosis‐related T cell subsets in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
An integrated multi‐omics analysis delineates the prognostic landscape of T‐cell subsets in hepatocellular carcinoma. DPT cells and HBEGF‐related signals are associated with poor survival in hepatocellular carcinoma. Endothelial‐derived HBEGF recruits DPT cells, which in turn up‐regulate the EMT signatures and drive the migration of hepatocellular ...
Guangzu Cui, Erya Hu, Qingping Peng, Xin Zhou, Yu Zhao, Haicong Liu, Xinwen Wang, Yihong Chen, Hong Shen, Shan Zeng, Jiayao Ma   +10 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation

Cell Death and Disease, 2018
It is critical to understand the molecular mechanisms of hepatocarcinogenesis in order to prevent or treat hepatocellular carcinoma (HCC). The development of HCC is commonly associated with hepatocyte death and compensatory proliferation.
Na Shang, Thomas Bank, Xianzhong Ding, P. Breslin, Jun Yu Li, Baomin Shi, W. Qiu   +6 more
semanticscholar   +1 more source

Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice

OncoTarget, 2017
Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease.
Koki Obara, Y. Shirakami, Akinori Maruta, T. Ideta, Tsuneyuki Miyazaki, Takahiro Kochi, Hiroyasu Sakai, Takuji Tanaka, M. Seishima, M. Shimizu   +9 more
semanticscholar   +1 more source

Nitroxide‐Mediated Fluorescence Quenching: Synthesis and Applications for the Detection of ROS in Biological Systems

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
ABSTRACT Profluorescent nitroxides (PFNs) have established themselves as powerful tools for monitoring oxidative processes and subcellular redox dynamics by reactive oxygen species (ROS). Their characteristic “off–on” behavior arises from the efficient, proximity‐driven quenching of covalently bound fluorophores by paramagnetic nitroxide radicals ...
Haider N. Sultani, Ludger A. Wessjohann, Daniel G. Rivera, Dariush Hinderberger, Bernhard Westermann   +4 more
wiley   +1 more source

Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice

BioMed Research International, 2018
Diethylnitrosamine (DEN) induces hepatocarcinogenesis, increasing mitotic hepatocytes and leading to chronic inflammation. In addition, type 1 diabetes mellitus (T1DM) is also characterized by a proinflammatory state and by requiring insulin exogenous ...
A. Arboatti, Flavia Lambertucci, M. Sedlmeier, G. Pisani, J. Monti, M. Alvarez, D. Francés, M. T. Ronco, C. Carnovale   +8 more
semanticscholar   +1 more source