Results 21 to 30 of about 2,632 (156)

Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways

Antioxidants, 2022
Hepatocellular carcinoma (HCC) represents around 85% of all known types of liver cancers and is estimated to be the fifth most common cause of cancer-related death worldwide.
Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed   +6 more
doaj   +1 more source

Ameliorative Effects of Aspergillus awamori against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in a Rat Model: Regulation of Cyp19 and p53 Gene Expression

Antioxidants, 2021
Hepatocellular carcinoma (HCC) is the most common cancer in humans. Despite advances in its treatment, liver cancer remains one of the most difficult cancers to treat.
Doaa H. Assar, Abd-Allah A. Mokhbatly, Emad W. Ghazy, Amany E. Ragab, Samah Abou Asa, Walied Abdo, Zizy I. Elbialy, Nora Elbialy Mohamed, Ali H. El-Far   +8 more
doaj   +1 more source

A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d

, 2023
Primary liver cancer (PLC) can be classified in hepatocellular (HCC), cholangiocarcinoma (CCA), and combined hepatocellular-cholangiocarcinoma (cHCC-CCA).
Remmerie, Michiel, Wu, Hanghang, Roskams, Tania, Francisco J. Cubero, Veerle Janssens, Hanghang Wu, Judit Domènech Omella, Iris Verbinnen, Michiel Remmerie, Verbinnen, Iris, Domènech Omella, Judit, Cortesi, Emanuela E., Cubero Palero, Francisco Javier, Emanuela E. Cortesi, Cubero, Francisco J, Janssens, Veerle, Cortesi, Emanuela E, Tania Roskams, Domènech Omella, Judith   +18 more
core   +1 more source

Protective Effects of Naringin–Dextrin Nanoformula against Chemically Induced Hepatocellular Carcinoma in Wistar Rats: Roles of Oxidative Stress, Inflammation, Cell Apoptosis, and Proliferation

Pharmaceuticals, 2022
Nanotechnology holds great promise for the development of treatments for deadly human diseases, such as hepatocellular carcinoma (HCC). In the current study, we compared the hepatoprotective effects of naringin–dextrin nanoparticles (NDNPs) against HCC ...
Eman E. Mohamed, Osama M. Ahmed, Adel Abdel-Moneim, Khairy M. A. Zoheir, Basem H. Elesawy, Ahmad Al Askary, Ahmed Hassaballa, Ahmed A. G. El-Shahawy   +7 more
doaj   +1 more source

Biochemical, hematological, peripheral smear and weight evaluation of low dose Epigallocatechin Gallate in Diethylnitrosamine administered rats

Journal of Contemporary Medicine, 2023
Background: Currently, with the development of technology, the use of many chemicals especially Diethylnitrosamine (DEN) in agriculture and industry has increased.
Hadi Geylan, Cennet Ragbetli, Okan Arıhan, Zübeyt Bilici, Murat Çetin Rağbetli   +4 more
doaj   +1 more source

Organ toxicity of diethylnitrosamine and capsaicin in mice – in vivo study

Annales Universitatis Paedagogicae Cracoviensis Studia Naturae, 2018
Diethylnitrosamine (DEN) is proven to be toxic to kidneys and liver and to act as a potent carcinogen mainly in liver. Capsaicin (CAP) is an alkaloid produced by Capsicum genus plants and is considered to be a protective agent against toxicity and ...
Vendula Kuchařová, Ondřej Daněk , Miša Škorič, Ivana Veselá, Jaroslava Tomenendálová   +4 more
doaj   +1 more source

Ellagic acid could prevent experimentally induced oxidative stress in rats [PDF]

Eurasian Journal of Veterinary Sciences, 2022
Aim: Reactive oxygen species (ROS) are produced during the metabolism of diethylnitrosamine (DEN) and phenobarbital (PB). Ellagic acid (EA) is a natural biologically active polyphenol with antioxidant activity.
Mehmet Ali Kisacam, Gonca Ozan Kocamuftuoglu, Enver Ozan, Sema Temizer Ozan   +3 more
doaj  

Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis

Current Issues in Molecular Biology, 2022
Chronic inflammation and cancer stem cells are known risk factors for tumorigenesis. The aetiology of hepatocellular carcinoma (HCC) involves a multistep pathological process that is characterised by chronic inflammation and hepatocyte damage, but the ...
Chun-Chieh Wu, Chien-Ju Lin, Kong-Kai Kuo, Wan-Tzu Chen, Chen-Guo Ker, Chee-Yin Chai, Hung-Pei Tsai, Sheau-Fang Yang   +7 more
doaj   +1 more source

Effect of Menthol on SFRP1 Expression Level and HIF-1α/VEGF Signaling in Diethylnitrosamine-induced Kidney Damage in Male Mice [PDF]

Journal of Ardabil University of Medical Sciences, 2023
Background: Many scientific Researches have shown that diethylnitrosamine, which is used to induce liver carcinoma, has destructive effects on the kidney. Menthol is a monoterpene type with antioxidant, anti-inflammatory, and anti-cancer effects.
Samaneh Alijanian, Masoumeh Asle Rousta, Golnaz Asaadi Tehrani   +2 more
doaj  

Metformin Improves Biochemical and Pathophysiological Changes in Hepatocellular Carcinoma with Pre-Existed Diabetes Mellitus Rats

Pathogens, 2021
Hepatocellular carcinoma (HCC) is one of the world’s most widely recognized malignant tumors that accounts for 90% of all the primary liver cancers and is a major cause of death from cancer, representing half a million deaths per year.
Maysa A. Mobasher, Mousa O. Germoush, Hala Galal El-Tantawi, Karim Samy El-Said   +3 more
doaj   +1 more source