Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis by modulating inflammation-related factors in rats [PDF]
Journal of Toxicologic Pathology, 2018 Hiroki Sakai, Tokuma Yanai
exaly +4 more sources
Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog [PDF]
Journal of Veterinary Medical Science, 2020 A 16 years old neutered male Miniature Dachshund with 1-year history of repetitive administration of zonisamide for treatment of epileptic seizure was presented for vomiting, anorexia and diarrhea. Serum biochemistry showed a markedly elevated ALP level. The dog died 6 days after the presentation and a necropsy was performed.
TAKAMI, Yuki +6 more
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The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]
J Clin Invest, 2016 Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer +24 more
core +2 more sources
Radiology Case Reports, 2023 Spontaneous necrosis of hepatocellular carcinoma (HCC) is rare and difficult to diagnose preoperatively if it occurs before the definitive diagnosis of HCC; this is because spontaneous necrosis of HCC exhibits various patterns in imaging studies.
Yu Ota, MD, PhD +9 more
doaj +3 more sources
Tumour necrosis as a prognostic indicator in hepatocellular carcinoma [PDF]
BMC CancerAbstract Background Tumour necrosis is linked to worse outcomes in hepatocellular carcinoma (HCC). However, the relationship between the extent of necrosis in HCC and survival outcomes remains unclear, partly due to the lack of a standardised assessment method.
Niklas Sarelin +7 more
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European Journal of Radiology Open, 2016 Purpose: To correlate intra voxel incoherent motion (IVIM) diffusion parameters of liver parenchyma and hepatocellular carcinoma (HCC) with degree of liver/tumor enhancement and necrosis; and to assess the diagnostic performance of diffusion parameters ...
Suguru Kakite +5 more
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Antitumor necrosis factor‑α antibodies as a novel therapy for hepatocellular carcinoma
Experimental and Therapeutic Medicine, 2018 Hepatocellular carcinoma (HCC) accounts for many cases of cancer-associated mortality. Tumor necrosis factor (TNF)-α is a key mediator of tumor-promoting inflammation. It has been demonstrated that anti-TNF-α treatments have preclinical benefits for multiple types of cancer, however their potential for treating HCC remains unclear. Through fluorescence-
Wei Li, Yong‐Bin Jian
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TACE combined with sorafenib induces complete remission in an elderly patient with hepatocellular carcinoma, hepatic venous tumor thrombus, and diffuse lung metastasis: a case study and literature review [PDF]
Frontiers in OncologyHepatocellular carcinoma (HCC) with hepatic venous tumor thrombus (HVTT) and synchronous lung metastases has a poor prognosis and limited treatment options.
Zhao Guangsheng +7 more
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Kanzo, 1989 肝細胞癌(HCC)の自然壊死と肝動脈塞栓術(TAE)による壊死との質的差を明らかにする目的で,TAE施行40例と非施行24例とを病理組織学的に比較検討した.非施行例の壊死は,腫瘍結節または厚い索状構造をとるHCC胞巣の中心部壊死を主体とし,個々の壊死細胞が遊離し類壊死細胞と混在する像を呈した.TAE施行例では広範で均一な性状を示す凝固壊死巣を形成し,非施行例に比し多量のヘマトイジン・カルシウム沈着を認めるものが多かった.これらの性状の差は虚血の発現速度と程度の差によるものと考えた.またTAE施行後の変化は,壊死進行期,器質化期および瘢痕化期の三期に大別できた.TAE施行後も生存する腫瘍組織には門脈血行があるとされているが,HCCにはTAEにより塞栓される主栄養動脈のみでなく ...
Akinari Tabaru
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Total Necrosis of Hepatocellular Carcinoma Due to Spontaneous Occlusion of Feeding Artery
Yonsei Medical Journal, 2002 Spontaneous total necrosis of hepatocellular carcinoma is extremely rare, with only 15 cases reported to date in the English literature, and the involved mechanism remains unresolved. This paper describes a case of spontaneous necrosis of hepatocellular carcinoma in a 70-year-old man with chronic hepatitis.
Sang Cheol Lee +9 more
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