Results 101 to 110 of about 541,993 (403)

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. [PDF]

, 2019
Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury in humans.
Hunt, C Anthony, Jaeschke, Hartmut, Kennedy, Ryan C, McGill, Mitchell R, Ropella, Glen EP, Smith, Andrew K   +5 more
core  

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Scientific Reports, 2018
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes.
Marion Régnier, Arnaud Polizzi, S. Smati, Céline Lukowicz, A. Fougerat, Y. Lippi, Edwin Fouché, F. Lasserre, C. Naylies, Colette Bétoulières, V. Barquissau, E. Mouisel, J. Bertrand-Michel, Aurélie Batut, T. Saati, C. Canlet, Marie Tremblay-Franco, S. Ellero-Simatos, D. Langin, C. Postic, W. Wahli, N. Loiseau, H. Guillou, A. Montagner   +23 more
semanticscholar   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Hepatocyte‐derived extracellular vesicles regulate liver regeneration through a negative feedback mechanism

Journal of Extracellular Biology
While significant progress has been made in understanding various aspects of liver regeneration, the molecular mechanisms responsible for the initiation and termination of cell proliferation in the liver following massive tissue loss or injury of liver ...
Mina McGinn, Christopher Rabender, Ross Mikkelsen, Vasily Yakovlev   +3 more
doaj   +1 more source

Plasmodium cellular effector mechanisms and the hepatic microenvironment

Frontiers in Microbiology, 2015
Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular effector mechanisms capable of eliminating Plasmodium liver stages.
Ute eFrevert, Urszula eKrzych
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Cryopreservation of Human Hepatocyte by Sugar-alcohol based CPAs

Zhileng xuebao, 2012
Different types of sugar alcohol is usually used as cryoprotective agents (CPAs) to preserve human hepatocytes. In this study, a new types of sugar alcohol based CPAs with low toxicity was explored by replacing Me2SO with D-sorbic alcohol, xylosic ...
Yang Bo, Shen Li, Huang Danhua, Liu Baolin   +3 more
doaj  

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

eLife, 2019
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed.
Takeshi Katsuda, Juntaro Matsuzaki, Tomoko Yamaguchi, Yasuhiro Yamada, Marta Prieto-Vila, Kazunori Hosaka, Atsuko Takeuchi, Yoshimasa Saito, Takahiro Ochiya   +8 more
doaj   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]

, 2008
Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H., Brockhoff, G., Christ, B., Jauch, Karl-Walter, Kirchner, S., Kunz-Schughart, L.A., Lichtenauer, M., Schlitt, H.-J., Stock, P., Thasler, Wolfgang E., Weiss, T.S.   +10 more
core   +1 more source