Results 131 to 140 of about 380,993 (362)

Rethinking Extracellular Vesicle Signaling

Advanced Materials, EarlyView.
Extracellular vesicles enable cell communication beyond intracellular cargo delivery. This perspective highlights two plausible surface‐based signaling modes: “bind‐and‐stay” and “bind‐and‐leave.” Transient binding to multiple cells challenges the one‐vesicle‐one‐cell model.
Wojciech Chrzanowski, Joy Wolfram
wiley   +1 more source

Author response: Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

, 2020
Jin Rong Ow, Matias J. Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave‐Gassiot, Chee Bing Ong, Markus R. Wenk, Weiping Han, Hyungwon Choi, Philipp Kaldis   +12 more
openalex   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, EarlyView.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells

Hepatic Medicine: Evidence and Research, 2020
Rajagopal N Aravalli,1 Daniel P Collins,2 Joel H Hapke,2 Andrew T Crane,3 Clifford J Steer4,5 1Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA; 2Cytomedical Design Group LLC, St. Paul, MN 55127, USA;
Aravalli RN, Collins DP, Hapke JH, Crane AT, Steer CJ   +4 more
doaj  

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Hepatocyte Nuclear Factor 3 Relieves Chromatin-mediated Repression of the α-Fetoprotein Gene [PDF]

, 1999
Alison J. Crowe, Ling Sang, Kelly Ke Li, Kathleen C. Lee, Brett T. Spear, Michelle Barton   +5 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Therapeutic Actions of Hepatocyte Extracellular Vesicles in a Murine Model of Diet-Induced Steatohepatitis with Fibrosis

Biomedicines
Introduction: Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver failure globally and is characterized by hepatic steatosis and inflammation, which may progress to fibrosis, the severity of which is highly predictive of ...
Xinlei Li, Ruju Chen, Sherri Kemper, Zhaohui Xu, David R. Brigstock   +4 more
doaj   +1 more source

Mmp23b Promotes Liver Development and Hepatocyte Proliferation Through the Tumor Necrosis Factor Pathway in Zebrafish [PDF]

, 2010
Qi Fei, Jianbo Song, Hanshuo Yang, Wei Gao, Ning‐Ai Liu, Bo Zhang, Shuo Lin   +6 more
openalex   +1 more source