Results 241 to 250 of about 541,993 (403)

Expression and function of CYP enzymes and hepatobiliary transporters in an improved long-term sandwich culture hepatocyte model. [PDF]

Sci Rep
Pacsuta J, Bárány N, Kiszelák K, Csíkvári O, Mártonné Tóth B, Jemnitz K, Gáborik Z.   +6 more
europepmc   +1 more source

Protective Effect of Green Tea Extract and Tea Polyphenols against the Cytotoxicity of 1,4-Naphthoquinone in Isolated Rat Hepatocytes [PDF]

, 1997
Chika Miyagawa, Chen Wu, David O. Kennedy, Teruyo Nakatani, Kimiko Ohtani, Senji Sakanaka, Mujo kim, Isao Matsui‐Yuasa   +7 more
openalex   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Liver regeneration: unraveling the molecular mechanisms and clinical application. [PDF]

J Transl Med
Wang N, Guo M, Zhang C, Jiang R, Bi J, Sun J, Liu B.   +6 more
europepmc   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Genetic Correction of the Most Common Mutation Causing Primary Hyperoxaluria Restores Enzyme Localization and Oxalate Metabolism. [PDF]

J Inherit Metab Dis
Keskinen T, Jalil S, Gümüşoğlu I, Juutila J, Kestilä N, Kuuluvainen E, Hietakangas V, Balboa D, Wartiovaara K, Hyvönen ME.   +9 more
europepmc   +1 more source

Liver X Receptor α–Induced Cannabinoid Receptor 2 Inhibits Ubiquitin‐Specific Peptidase 4 Through miR‐27b, Protecting Hepatocytes From TGF‐β

, 2019
Hongmin Wu, Tae Hyun Kim, Ayoung Kim, Ja Hyun Koo, Min Sung Joo, Sang Geon Kim   +5 more
openalex   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

Frontiers in Cell and Developmental Biology, 2020
Yu Li, Yu Li, Hongyan Ding, Leihong Liu, Yuxiang Song, Xiliang Du, Shibin Feng, Xichun Wang, Xiaobing Li, Zhe Wang, Xinwei Li, Jinchun Li, Jinjie Wu, Guowen Liu   +13 more
doaj   +1 more source

Iron-related intercellular communication in the liver: Main players and mechanisms. [PDF]

Eur J Clin Invest
Fonseca Ó, Oliveira PJ, Muckenthaler MU, Moreira AC, Gomes MS.   +4 more
europepmc   +1 more source