Results 251 to 260 of about 541,993 (403)

Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo

, 2008
Suchismita Panda, Ayman Isbatan, Guy R. Adami   +2 more
openalex   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Immune Determinants of MASLD Progression: From Immunometabolic Reprogramming to Fibrotic Transformation. [PDF]

Biology (Basel)
Xu S, Zhang Z, Zhou Z, Guo J.
europepmc   +1 more source

Effects of taurolithocholate, a Ca2+-mobilizing agent, on cell Ca2+ in rat hepatocytes, human platelets and neuroblastoma NG108-15 cell line [PDF]

, 1991
Jean‐François Coquil, B Berthon, Nathalie Chomiki, Laurent Combettes, Philippe Jourdon, C D Schteingart, Serge Erlinger, M Claret   +7 more
openalex   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Modeling pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease and therapeutic drug screening using hESC-derived mature polarized hepatocyte organoids. [PDF]

Stem Cell Res Ther
Qin C, Wu H, Liao P, Yan W, Shi X, Xie J, Liu S, Chen S, Cao X, Zhou Y, Duan Y.   +10 more
europepmc   +1 more source

Erratum: Safety and efficacy of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with critical limb ischemia [PDF]

, 2016
Melina R. Kibbe, A T Hirsch, Farrell O. Mendelsohn, M Davies, H. Pham, Jorge Saucedo, William A. Marston, W-B Pyun, S-K Min, Brian G. Peterson, Anthony J. Comerota, David Choi, Joshua A. Ballard, R A Bartow, Douglas W. Losordo, W Sherman, Vickie R. Driver, Emerson C. Perin   +17 more
openalex   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Correction: Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. [PDF]

Lipids Health Dis
Nan Y, Wang R, Zhao S, Han F, Wu WJ, Kong L, Fu N, Kong L, Yu J.   +8 more
europepmc   +1 more source

Dendrobine inhibits hepatic gluconeogenesis and promotes glycogen synthesis through control of m⁶A RNA modification of PEPCK/G6Pase by METTL3 in hepatocytes

Xinguo Hou, Xiaohua Zheng, Qian Lin, Xiaomei Wang, Zhaozhen Liu   +4 more
openalex   +1 more source