Results 261 to 270 of about 380,993 (362)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Analgesic strategies for ischaemic pain in chronic limb-threatening ischaemia: a systematic review and meta-analysis. [PDF]

Pain Rep
Davies H, Boalot A, Howitt A, Vleugels MJ, Tam SKP, Kwan JY, Black S, Francis I, Bull C, Mees BME, Mitchell S, Russell D.   +11 more
europepmc   +1 more source

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation [PDF]

, 2017
Galemmo, Robert A, Jr, Han, Zhenfu, Janetka, James W, Klampfer, Lidija, Owusu, Benjamin Y, Thomas, Shantasia, Venukadasula, Phanindra   +6 more
core   +2 more sources

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

iRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia-reperfusion injury. [PDF]

Cell Death Dis
Calligaris M, Perriera R, Carcione C, Miceli V, Pinto ML, Busà R, Amico G, Bulati M, Amato C, Pagano D, Conaldi PG, Scilabra SD, Pinzani M, Zito G.   +13 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Kupffer cells control neonatal hepatic metabolism via Igf1 signaling. [PDF]

Development
Makdissi N, Hirschmann DJ, Frolov A, Sado I, Bennühr B, Nikolka F, Cheng J, Blank-Stein N, Viola MF, Yaghmour M, Arnold P, Bonaguro L, Becker M, Thiele C, Meissner F, Hiller K, Beyer MD, Mass E.   +17 more
europepmc   +1 more source

Association between Hepatocyte Growth Factor (HGF) Gene Polymorphisms and Serum HGF Levels in Patients with Rheumatoid Arthritis

, 2014
Fatih Kara, Abdülkadir Yıldırım, Musa Gümüşdere, Saliha Karatay, Kadir Yıldırım, Ebubekîr Bakan   +5 more
openalex   +2 more sources