Results 321 to 330 of about 541,993 (403)

Impact of neoadjuvant cetuximab on liver function and tumor reduction in a murine model of selective portal vein ligation. [PDF]

Clin Exp Metastasis
Tirado-Rodríguez G, Ruiz-Montesinos I, Iturrizaga S, García Ruiz de Gordejuela A, Aizpiolea P, Alonso-Alconada D, García-Alonso I, Herrero de la Parte B.   +7 more
europepmc   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration. [PDF]

Biology (Basel)
Han J, Sung A, Jeong H, Jung Y.
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Sex-Specific Downregulation of CDK5RAP3 Exacerbates ER Stress-Mediated Inflammation and Apoptosis in CCl₄-Induced Acute Liver Injury. [PDF]

Genes (Basel)
Ruan J, Dong Q, Xu F, Jin Y, Yang Y, Li J, Cai Y.   +6 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications. [PDF]

Adv Drug Deliv Rev
Nah H, Michell AR, Rogy KM, Lally OJ, Khetani SR.   +4 more
europepmc   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Genome-wide CRISPR screen identifies ACSL3 as a regulator of lipotoxicity and progression of MASLD. [PDF]

Hepatol Commun
Myojin Y, Kodama T, Takahashi R, Nagasawa H, Kondo Y, Yusa K, Yoshida-Hashidate T, Shindou H, Furuta K, Murai K, Saito Y, Hikita H, Takehara T.   +12 more
europepmc   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source