Results 321 to 330 of about 380,993 (362)
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1996
The use of in vitro and in vivo systems to evaluate hepatic drug uptake and metabolism, cytochrome P450 induction, drug interactions affecting hepatic metabolism, hepatotoxicity, and cholestasis is an essential part of the drug development process (Tavoloni and Boyer, 1980; Powis et al., 1989; Bertrams and Ziegler, 1991; Jurima-Romet and Huang, 1992 ...
E L, LeCluyse +3 more
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The use of in vitro and in vivo systems to evaluate hepatic drug uptake and metabolism, cytochrome P450 induction, drug interactions affecting hepatic metabolism, hepatotoxicity, and cholestasis is an essential part of the drug development process (Tavoloni and Boyer, 1980; Powis et al., 1989; Bertrams and Ziegler, 1991; Jurima-Romet and Huang, 1992 ...
E L, LeCluyse +3 more
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Archives Internationales de Physiologie et de Biochimie, 1985
Cell volume regulation has been studied during isolated dog liver perfusion. In presence of ouabain (10(-4) M) rapid but quantitatively matched exchange of K for Na occurs and the cellular volume is maintained until (90 min later) intracellular K concentration falls below 80 mEq/litre.
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Cell volume regulation has been studied during isolated dog liver perfusion. In presence of ouabain (10(-4) M) rapid but quantitatively matched exchange of K for Na occurs and the cellular volume is maintained until (90 min later) intracellular K concentration falls below 80 mEq/litre.
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Cryopreservation of Hepatocytes
2014The use of cryopreserved hepatocytes has increased in the last decade due to the improvement of the freezing and thawing methods, and has even achieved acceptance by the US Food and Drug Administration for use in drug metabolizing enzyme induction studies.
Nicola J, Hewitt, Albert P, Li
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2006
In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. In this chapter, the practical aspects of the two-step collagenase perfusion method, modified from the ...
Elaut, Greetje +6 more
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In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. In this chapter, the practical aspects of the two-step collagenase perfusion method, modified from the ...
Elaut, Greetje +6 more
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Experientia, 1968
In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair
Science, 2021Lingjuan He, Wenjuan Pu, Xiuxiu Liu
exaly
1980
The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis
Gut, 2021Eun Hee Koh +2 more
exaly