Results 51 to 60 of about 251,001 (160)

Cryopreservation of Human Hepatocyte by Sugar-alcohol based CPAs

Zhileng xuebao, 2012
Different types of sugar alcohol is usually used as cryoprotective agents (CPAs) to preserve human hepatocytes. In this study, a new types of sugar alcohol based CPAs with low toxicity was explored by replacing Me2SO with D-sorbic alcohol, xylosic ...
Yang Bo, Shen Li, Huang Danhua, Liu Baolin   +3 more
doaj  

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

eLife, 2019
Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed.
Takeshi Katsuda, Juntaro Matsuzaki, Tomoko Yamaguchi, Yasuhiro Yamada, Marta Prieto-Vila, Kazunori Hosaka, Atsuko Takeuchi, Yoshimasa Saito, Takahiro Ochiya   +8 more
doaj   +1 more source

Rat hepatocyte spheroids formed on temperature-responsive PIPAAm polymer-grafted surface maintain long-term differentiated hepatocyte function

, 2014
Background. Although the development of a practicable culture method to maintain long-term hepatocyte function is highly desirable, hepatocytes lose their liver-specific functions rapidly on regular collagen-coated dishes. In this study, we evaluated the
Takatsuki, Mitsuhisa, Soyama, Akihiko, Tomonaga, Tetsuo, Yamanouchi, Kosho, Kuroki, Tamotsu, Koji, Takehiko, Eguchi, Susumu   +6 more
core  

Drug Delivery Strategies for Antivirals against Hepatitis B Virus

Viruses, 2018
Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality.
Latavia Singh, Sunaina Indermun, Mershen Govender, Pradeep Kumar, Lisa C. du Toit, Yahya E. Choonara, Viness Pillay   +6 more
doaj   +1 more source

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

, 2019
Obesity triggers the genesis of non-alcoholic fatty liver diseases (NAFLD), which involves alterations of regulatory transcription networks and of hepatocyte-selective epigenomes.
Barilla, Serena, Mendoza, Arturo, Bart Staels (15303), Goñi, Saioa, Tarja Schröder (6268779), Giudici, Marco, Fawaz Alzaid (483832), Huang, Zhiqiang, Jakobsson, Tomas, Alzaid, Fawaz, Marco Giudici (5754596), van Gaal, Luc, Ning Liang (3777817), Damdimopoulos, Anastasius, Parini, Paolo, Venteclef, Nicolas, Lise-Lotte Vedin (179687), Hollenberg, Anthony, Francque, Sven, Raoul Kuiper (399255), Treuter, Eckardt, Sven Francque (602244), Saioa Goñi (358304), Schröder, Tarja, Lefebvre, Philippe, Kuiper, Raoul, Luc Van Gaal (157145), Ahmed, Osman, Anthony Hollenberg (6268780), Eckardt Treuter (9783), Vedin, Lise-Lotte, Fan, Rongrong, Staels, Bart, Zhiqiang Huang (1552234), Matteo Pedrelli (545877), Serena Barilla (6268772), Arturo Mendoza (6268774), Anastasius Damdimopoulos (6268764), Rongrong Fan (6261539), Liang, Ning, Pedrelli, Matteo, Philippe Lefebvre (166527), Tomas Jakobsson (6268767), Nicolas Venteclef (154214), Osman Ahmed (524943), Paolo Parini (87438)   +45 more
core   +1 more source

Mechanism of Hepatocyte Apoptosis

, 2016
Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug ...
Xi-Bing Quan, Wen-Jiao Zeng, Lei Cao, Ming-Jie Wang, Xiao-Ou Yang   +4 more
core   +1 more source

Effects of days-fasting and refeeding on growth, biochemical and histometric liver parameters in pacu Piaractus mesopotamicus [PDF]

Brazilian Journal of Biology
This study evaluated the effects of days-fasting followed by days-refeeding on growth, biochemical, and hepatic parameters in pacu (Piaractus mesopotamicus). One hundred and twenty juveniles P. mesopotamicus with initial average weight and length of 47.7
K. N. N. Farias, A. L. N. Silva, T. V. Silva, S. F. Gonçalves, K. V. Kuibrida, C. A. Honorato, R. A. Rodrigues, M. S. Owatari, C. F. M. Campos, L. F. Belussi, C. E. Fernandes   +10 more
doaj   +1 more source

Differentiation of hepatocyte-like cells from piPSCs.

, 2014
(A) A protocol outline describing Method I of hepatocyte differentiation from piPSCs. (B) Morphological changes during piPSCs differentiation to hepatocyte-like cells using Method I.
Ying Ao (326333), Lei Yang (102719), Jocelyn Danielle Mich-Basso (116838), Bo Lin (116835)   +3 more
core   +1 more source

Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice

, 2015
Makoto Umeda,1 Masaki Hiramoto,1,2 Takeshi Imai1 1Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan; 2Department of Biochemistry, Tokyo Medical University, Tokyo, Japan Abstract: Estrogens play ...
Hiramoto M, Umeda M, Imai T
core  

Which in vitro models could be best used to study hepatocyte polarity?: Hepatocyte polarity models

, 2008
International audienceThe correct functioning of the liver is ensured by the setting and the maintenance of hepatocyte polarity. The complex polarity of the hepatocyte is characterized by the existence of several basolateral and apical poles per cell ...
Decaens, Catherine, Cassio, Doris, Brigitte Grosse, Durand, Marjorie, Marjorie Durand, Grosse, Brigitte, Catherine Decaens, Doris Cassio   +7 more
core   +1 more source