Results 161 to 170 of about 200,853 (296)

Hepatocyte growth factor in biosheets promotes autonomous regeneration of cutaneous tissue after transplantation onto a full-thickness skin defect. [PDF]

Mater Today Bio
Suzuki K, Komura H, Konno R, Kawashima Y, Watanabe E, Sato H, Matsumoto K, Inaki R, Kanazawa S, Asawa Y, Hikita A, Hoshi K, Fujishiro J, Komura M.   +13 more
europepmc   +1 more source

Plasma hepatocyte growth factor as a noninvasive biomarker in small cell lung cancer. [PDF]

BMC Cancer, 2023
Zhao C, Tong L, Liu B, Qi F, Zhang Z, Guo Y, Liu Y, Wang Y, Zhang L, Lu B, Li B, Zhang T.   +11 more
europepmc   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

The role of hepatocyte growth factor in the relationship between body fat distribution and plasma markers of glucose metabolism: a cross-sectional study. [PDF]

Diabetol Metab Syndr
Zakic K, Freuer D, Linseisen J, Meisinger C.   +3 more
europepmc   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Function of histamine-driven cancer-associated fibroblast and hepatocyte growth factor in the progression of cholangiocarcinoma. [PDF]

Gastroenterol Rep (Oxf)
Wang X, Sheng G, Yan Z, Shi A, Liu Z, Tang Y, Li G, Zhang Z.   +7 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging

Angewandte Chemie, EarlyView.
Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas, Amy L. Parkhurst, Ming‐Fo Hsu, Christopher Hou, Fawaz G. Haj, Elizabeth K. Neumann   +5 more
wiley   +2 more sources