Results 211 to 220 of about 79,825 (316)

Hepatoprotective Evidence for the Individual Ingredients of a Standardized Sri Lankan Polyherbal Formulation: A Scoping Review. [PDF]

Cureus
Jayawardhana GJ, Somaratne G, Kariyawasam KP, Chandrasekara A.   +3 more
europepmc   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

SWI/SNF Chromatin Remodelling Complex in Hepatic Physiology: Mechanistic Insights Into Development, Homeostasis and Pathogenesis. [PDF]

J Cell Mol Med
Li R, Zhang B, Wei X, Yang J, Zhou Y.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

Int J Mol Sci
Mastoridou EM, Goussia AC, Kataki A, Koniaris E, Glantzounis GK, Papoudou-Bai A, Kanavaros P, Charchanti AV.   +7 more
europepmc   +1 more source

GENETIC STUDY OF HEPATOCYTE NUCLEAR FACTOR-1 ALPHA (HNF-1Α) MUTATIONS IN DIABETES MELLITUS PATIENTS

Fusvita Merdekawati, Ira Gustira Rahayu, Aditya Juliastuti, Citra Amaniah Anhar, Zulfikar Ali Hasan, Larasati Putri Maynar   +5 more
openalex   +2 more sources

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model

Pediatric Investigation, EarlyView.
THBA (3α,6α,7α,12α‐Tetrahydroxy‐10β,13β‐pentanoic acid) administration can alleviate cholestatic liver injury, hepatocellular necrosis, inflammatory response, bile duct hyperplasia, and portal fibrosis in the Zfyve19−/− mouse model. This evaluation encompasses various parameters, including serum biochemistry, liver histology, immunostaining, and ...
Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang   +8 more
wiley   +1 more source

Autophagy related 14 protects against liver injury by inhibiting multiple cell death pathways. [PDF]

eGastroenterology
Kim HG, Huang M, Wang S, Zhang Y, Li K, Liu S, Dong C, Yang X, Cho JH, Chowdhury K, Stein B, Wan J, Dong XC.   +12 more
europepmc   +1 more source

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues. [PDF]

Toxicol Rep
Elcombe M, Wallace S, Plummer S.
europepmc   +1 more source