Results 281 to 290 of about 334,700 (354)

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

Cell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong, Kangxin He, Yu Liu, Xingyu Luo, Kamran Ashraf, Jinzhao He, Weifeng Li, Lihua Yang, Touseef Ur Rehman, Mingwei Shen, Qinbiao Yan, Ali Mohsin, Shusen Zheng, Zhe Yang, Meijin Guo   +14 more
wiley   +1 more source

Enhancement of hepatic differentiation from induced pluripotent stem cells by suppressing epithelial-mesenchymal transition. [PDF]

Hepatol Commun
Li N, Wei R, Yuan Y, Deng M, Hu Y, Cheng CW, Yang J, Ho WI, Au KW, Tse YL, Li F, Wu X, Lau YM, Liao S, Ma S, Liu P, Ng KM, Esteban MA, Tse HF.   +18 more
europepmc   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions. [PDF]

MedComm (2020)
Yuan H, Xu R, Li S, Zheng M, Tong Q, Xiang M, Zhang Y.   +6 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease. [PDF]

Circ Genom Precis Med
Soubeyrand S, Lau P, Nikpay M, Ma L, Bjorkegren JLM, McPherson R.   +5 more
europepmc   +1 more source

Shortcut to the needle in the haystack? Screening for maturity onset diabetes of the young in a population of women with gestational diabetes

Diabetic Medicine, Volume 42, Issue 5, May 2025.
Abstract Aims Pregnant women are occasionally misdiagnosed with gestational diabetes (GDM) when they may have glucokinase monogenic diabetes (GCK‐MODY). Differentiating between GCK‐MODY and GDM is critical due to the distinct treatment strategies required during and after pregnancy.
Sine Knorr, Laura L. Knudsen, Anne L. Madsen, Lene R. Madsen, Lene Mortensen, Henrik H. Thomsen, Lars Peter Sørensen, Per G. Ovesen, Jens Fuglsang, Ulla Kampmann   +9 more
wiley   +1 more source

Roles of extracellular vesicles from different origins in metabolic-associated fatty liver disease: progress and perspectives. [PDF]

Front Immunol
Wang J, Bao S, An Q, Li C, Feng J.
europepmc   +1 more source

Real world evidence of insulin and biosimilar insulin therapy—Opportunities to improve adherence, outcomes and cost‐effectiveness

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Insulin has been discovered for more than a century; however, its benefits to people with diabetes are yet to be fully realized due to barriers related to access, quality of care and costs. Insulin therapy remains the cornerstone of diabetes management. The multicausality of diabetes and its subtypes calls for comprehensive phenotyping and use
Aimin Yang, Jiazhou Yu, Johnny T. K. Cheung, Juliana C. N. Chan, Elaine Chow   +4 more
wiley   +1 more source

Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Gao J, Lu W, Xin Y, Ma H, Sheng X, Gao G, Kang X, Jiang S, Zhao Y, Lv Y, Niu Y, Liang Y, Wang H.   +12 more
europepmc   +1 more source