Results 171 to 180 of about 41,374 (252)

Cellular Anti-Apoptotic Effects of Dapagliflozin in Methotrexate-Induced Liver Toxicity: Bax/Bcl-2/Cyt-C/Cas-9/Cas-3 Signaling Pathway. [PDF]

Int J Mol Sci
Sarman E, Asci H.
europepmc   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Oxidative Stress and Alcohol-Related Hepatitis: A Role for Future Therapies. [PDF]

Antioxidants (Basel)
D'Arcangelo F, Rajoriya N, Lalor PF.
europepmc   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice. [PDF]

Int J Mol Sci
Wang H, Hu S, Wang J, Gopoju R, Lin L, Gunawardana L, Wang X, Yin L, Zhang Y.   +8 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Gliclazide Challenge Testing as an Alternative Diagnostic Tool for Hepatocyte Nuclear Factor-1-Alpha Maturity Onset Diabetes of the Young. [PDF]

Eur J Case Rep Intern Med
Pandya S, Khairati R, Mann J, Archer L, Saravanan P, Ereneta F, Patel V.   +6 more
europepmc   +1 more source

Glycyrrhizin preparations in liver diseases: a narrative review of mechanisms and therapeutic potential. [PDF]

Front Pharmacol
Ma T, Hao H, Wang S, Qiu D, Cao W, Deng W, Wang S, Li X, Zhang Z, Wei X, Yao L, Gao Z, Yi W, Liu R, Li M.   +14 more
europepmc   +1 more source

Biocompatible Sulfobetaine Polymer‐Artemisinin Conjugates Inducing Ferroptosis in Cancer Cells: Synthesis by Mechanochemical Solid‐State Polymerization and Characterization

Macromolecular Rapid Communications, EarlyView.
The amphiphilic copolymer incorporating a hydrophobic chain conjugated with artesunate into a biocompatible sulfobetaine polymer is synthesized by solid‐state copolymerization of sulfobetaine methacrylate and methacrylamide derivative conjugating artesunate.
Naoki Doi, Yukinori Yamauchi, Yasushi Sasai, Ryosuke Nagai, Ayaka Koike, Madoka Ikawa, Toru Yoshimoto, Satoshi Yamada, Masayuki Kuzuya, Shin‐ichi Kondo   +9 more
wiley   +1 more source

The role of HNF4α in adenocarcinoma. [PDF]

Biochem Soc Trans
Essel Dadzie H, Snyder EL.
europepmc   +1 more source