Results 321 to 330 of about 868,517 (361)

Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice. [PDF]

Cell Mol Gastroenterol Hepatol
Gao J, Lu W, Xin Y, Ma H, Sheng X, Gao G, Kang X, Jiang S, Zhao Y, Lv Y, Niu Y, Liang Y, Wang H.   +12 more
europepmc   +1 more source

Hepatic progenitor cells reprogrammed from mouse fibroblasts repopulate hepatocytes in Wilson's disease mice. [PDF]

Stem Cell Res Ther
Liu K, Li L, He Y, Zhang S, You H, Wang P.   +5 more
europepmc   +1 more source

STAT5: Understanding the Biology of KRAS^G12D-Driven Pancreatic Cancer. [PDF]

J Cell Mol Med
Papavassiliou KA, Adamopoulos C, Papavassiliou AG.   +2 more
europepmc   +1 more source

Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner. [PDF]

Sci Rep
Chancharoenthana W, Kamolratanakul S, Udompornpitak K, Wannigama DL, Schultz MJ, Leelahavanichkul A.   +5 more
europepmc   +1 more source

MiR-122-5p inhibits the epithelial mesenchymal transition of liver cancer cells by inducing hiPSCs to differentiate into hepatocyte-like cells. [PDF]

Eur J Histochem
Xing Q, Xu Y, Luo Y, Li C, Wang P, Kang B, Lu C.   +6 more
europepmc   +1 more source

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Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma

Journal of Hepatology, 1996
Liver-specific protein genes have multiple cis-/trans-acting elements, but those accountable for hepatocytic differentiation are unclear. An AT-rich core sequence (AT motif) is essential as a cis-acting element for the hepatic transcription. Homologous proteins hepatocyte nuclear factor-1 (HNF-1) and variant HNF-1 (vHNF-1) bind to this motif. The ratio
Hiroshi Itoh, Masato Kasuga, Hidekazu Nakabayashi, Yoshitake Hayashi, Toshiaki Ninomiya, Seitetsu Yoon, Kiyofumi Saijoh, Kyosuke Ohta, Taiki Tamaoki   +8 more
openaire   +3 more sources

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

Science, 1997
Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4–dependent genes that lack HNF-1 binding ...
Eleni Ktistaki, Iannis Talianidis
openaire   +2 more sources

Hepatocyte nuclear factor 1 negatively regulates amylin gene expression

Biochemical and Biophysical Research Communications, 2003
Maturity-onset diabetes of the young (MODY) is a monogenic subtype of Type 2 diabetes, defined as having an early age of onset, with a dominant inheritance pattern. Hepatocyte nuclear factor 1 (HNF1), which is encoded by the MODY3 gene, has been shown to bind the insulin promoter. Since the promoters of three pancreas-specific genes involved in glucose
Green, Janelle, Naot, Dorit, Cooper, Garth   +2 more
openaire   +4 more sources

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

Development, 1999
Abstract Genetic and molecular evidence indicates that visceral endoderm, an extraembryonic cell lineage, is required for gastrulation, early anterior neural patterning, cell death and specification of posterior mesodermal cell fates. We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor ...
Elena Barbacci, François Huetz, Michael Reber, Marie-Odile Ott, Silvia Cereghini, Christelle Breillat   +5 more
openaire   +3 more sources