Results 301 to 310 of about 628,453 (389)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation. [PDF]

PLoS Biol
Vasseur L, Gheeraert C, Dubois-Chevalier J, Very N, Guille L, Bou Saleh M, Boulet C, Sobolewski C, Loyer P, Berthier A, Legrand N, Corlu A, Gnemmi V, Lasailly G, Leteurtre E, Galinousky D, Bongiovanni A, Taront S, Toft NI, Grøntved L, Tulasne D, Furlan A, Ntandja-Wandji LC, Staels B, Lefebvre P, Dubuquoy L, Eeckhoute J.   +26 more
europepmc   +1 more source

Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice

Nature Biotechnology, 2007
H. Azuma, N. Paulk, Aarati R. Ranade, C. Dorrell, M. Al‐Dhalimy, E. Ellis, S. Strom, M. Kay, M. Finegold, M. Grompe   +9 more
semanticscholar   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Myeloid AEG-1/MTDH drives inflammation and hepatocellular dysfunction in diet-induced steatohepatitis. [PDF]

J Biol Chem
Raha S, Reghupaty SC, Qu X, Mendoza RG, Farrar D, Ermi AG, Davis E, Martin RK, Subler MA, Fisher PB, Windle JJ, Liu J, Sarkar D.   +12 more
europepmc   +1 more source

Identification and validation of a novel predictive signature based on hepatocyte-specific genes in hepatocellular carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]

Yujian He, Qi Wei, Xiaoli Xie, Huiqing Jiang   +3 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Expression of Selected Pharmacologically Relevant Transporters in Murine Non-Parenchymal Liver Cells Compared to Hepatocytes. [PDF]

Int J Mol Sci
Rönnpagel V, Ullrich A, Joseph C, Tzvetkov MV, Runge D, Grube M.   +5 more
europepmc   +1 more source

In vitro metabolism of Benzyl-4CN-BUTINACA and MDMB-4CN-BUTINACA using human hepatocytes and LC-QToF-MS analysis [PDF]

Caitlyn Norman, Kristin Webling, Dārta Štālberga, Lisa Maas, Johannes Tveit, Huiling Liu, Shimpei Watanabe, Svante Vikingsson, Henrik Gréen   +8 more
openalex   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source