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Cryopreservation of Hepatocytes
2014The use of cryopreserved hepatocytes has increased in the last decade due to the improvement of the freezing and thawing methods, and has even achieved acceptance by the US Food and Drug Administration for use in drug metabolizing enzyme induction studies.
Nicola J, Hewitt, Albert P, Li
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2006
In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. In this chapter, the practical aspects of the two-step collagenase perfusion method, modified from the ...
Elaut, Greetje +6 more
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In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. In this chapter, the practical aspects of the two-step collagenase perfusion method, modified from the ...
Elaut, Greetje +6 more
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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Nature Medicine, 2000E. Lagasse +9 more
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Experientia, 1968
In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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In der normalen und regenerierenden Rattenleber wurden Zentriolen gefunden. In der normalen Leberparenchymzelle erscheinen sie wahrscheinlich als Diplosomen. Haufig werden mehr als 2 Zentriolen in der einzelnen Leberparenchymzelle beobachtet, jedoch gibt es keine Anhaltspunkte fur eine zentriolare Replikation in den normalen Leberparenchymzellen ...
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Nature, 2011T. Kang +24 more
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
Nature, 2003Xin Wang +9 more
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Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Nature, 2003M. Álvarez-Dolado +8 more
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1980
The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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The purpose of this paper is not to survey current knowledge on aging of hepatic cells in general, but to summarize some of our own results that are concerned with the age changes in DNA content-based polyploidization of hepatocytes of three kinds of laboratory animals: mouse (1), fish (2), and house shrew (3).
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