Results 91 to 100 of about 347,060 (379)

A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]

, 2009
Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn, A. L. Gerbes, A. M. Vollmar, C. Coester, F. Hoffmann, G. Sass, G. Tiegs, G. Winter, J. Wagner, J. Zillies, S. Fuchs, S. Zahler   +11 more
core   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease [PDF]

, 2015
Hepatitis B virus (HBV) infection is a dynamic state of interactions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B (CHB) infection have shown an association between active viral replication and adverse
Farinati, Fabio, Gottardo, G, Rodr\uedguez Castro, K, Russo, FRANCESCO PAOLO, Scribano, L, Vanin, V   +5 more
core   +1 more source

Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis—An Evidence-based Consensus Guideline From the European Crohn's and Colitis Organization and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2018
Background and aim: Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality.
D. Turner, F. Ruemmele, E. Orlanski-Meyer, A. Griffiths, J. M. de Carpi, J. Bronský, G. Veres, M. Aloi, C. Strisciuglio, C. Braegger, A. Assa, C. Romano, S. Hussey, M. Stanton, M. Pakarinen, L. de Ridder, K. Katsanos, N. Croft, V. Navas-López, D. Wilson, S. Lawrence, R. Russell   +21 more
semanticscholar   +1 more source

Safety and Efficacy of Pelvic Reinforcement Procedure for Preventing Postoperative Perineal Hernia After Robotic Abdominoperineal Resection: A Single‐Center, Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to investigate the safety and efficacy of pelvic reinforcement procedure (PRP) in robotic abdominoperineal resection (Ro‐APR). PRP‐ had a significantly higher rate of imaged perineal hernia (PH) (39.2% vs. 6.7%, p = 0.005) and symptomatic PH (19.6% vs.
Yoshihiro Sakai, Shunsuke Kasai, Akio Shiomi, Shoichi Manabe, Yusuke Yamaoka, Yusuke Tanaka, Takahiro Igaki, Hiroyasu Kagawa, Yusuke Kinugasa   +8 more
wiley   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia, Coste, Sorina Cezara, Cozma, Angela, Negrean, Vasile, Orasan, Olga Hilda, Popovici, Ionela, Procopciuc, Lucia Maria, Sampelean, Dorel, Sitar Taut, Adela, Stefan, Andreea Maria, Tarmure Sarlea, Simina   +10 more
core   +1 more source

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge [PDF]

, 2016
End-stage liver disease caused by hepatitis C virus (HCV) infection is a major indication for liver transplantation. However, immediately after transplantation the liver graft of viremic patients universally becomes infected by circulating virus ...
Baumert, Thomas F., Cole, Sarah, Desombere, Isabelle, Fafi-Kremer, Samira, Farhoudi, Ali, Heydmann, Laura, Leroux-Roels, Geert, McKeating, Jane A., Meuleman, Philip, Patel, Arvind H., Pessaux, Patrick, Van Houtte, Freya, Verhoye, Lieven   +12 more
core   +3 more sources

Deep Learning Model for Predicting Operative Mortality After Total Gastrectomy: Analysis of the Japanese National Clinical Database (NCD)

Annals of Gastroenterological Surgery, EarlyView.
Deep learning‐based prediction model for operative mortality using the National Clinical Database (NCD). The model achieved a C‐statistic of 0.74. ABSTRACT Background Radical gastrectomy with lymph node dissection is the primary treatment for gastric cancer.
Ryosuke Fukuyo, Hiroyuki Yamamoto, Masanori Tokunaga, Yusuke Kinugasa, Yoshihiro Kakeji, Ken Shirabe   +5 more
wiley   +1 more source

Applications of Artificial Intelligence in Alpha-1 Antitrypsin Deficiency: A Systematic Review from a Respiratory Medicine Perspective

Medicina
Background and Objectives: Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition associated with chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD) and emphysema, and with liver involvement through a distinct ...
Manuel Casal-Guisande, Laura Villar-Aguilar, Alberto Fernández-Villar, Esmeralda García-Rodríguez, Ana Casal, María Torres-Durán   +5 more
doaj   +1 more source

Bile duct obstruction associated with pancreatitis in 46 dogs

Journal of Veterinary Internal Medicine, 2020
Background Pancreatitis is a common cause of extrahepatic bile duct obstruction (EHBDO) in dogs. Information describing the clinical course of dogs with pancreatitis associated bile duct obstruction (PABDO) is limited. Objectives To describe the clinical
Ashley R. Wilkinson, Stefanie M. DeMonaco, David L. Panciera, Cristiane C. Otoni, Michael S. Leib, Martha M. Larson   +5 more
doaj   +1 more source