Results 171 to 180 of about 146,077 (348)

Machine Learning‐Based High‐Throughput Screening, Molecular Modeling and Quantum Chemical Analysis to Investigate Mycobacterium tuberculosis MetRS Inhibitors

open access: yesChemistryOpen, EarlyView.
This paper provides a comprehensive approach using the ChEMBL database to construct a machine learning model that screened 10 million compounds from the eMolecules database. Two promising inhibitors targeting Mycobacterium tuberculosis methionyl‐tRNA synthetase were identified.
Rajesh Maharjan   +7 more
wiley   +1 more source

Dual‐Function Bis‐Tetraphenylethenes for Selective Metal Ion and Glutathione Detection and Current Transformer Application

open access: yesChemistryOpen, EarlyView.
In this study, it develops mono/bis‐substituted tetraphenylethenes that exhibit unique photophysical properties, including aggregation‐induced emission. These properties make them promising candidates for various applications, such as ion sensing and organic electronics.
Sinan Bayindir   +4 more
wiley   +1 more source

Prevention by Menadione of the Hepatotoxic Effects in Chickens Fed Rapeseed Meal

open access: bronze, 1979
Esther D. Israels   +3 more
openalex   +1 more source

Hepatotoxicity

open access: yesFolia Pharmacologica Japonica, 2008
Munehiro, Teranishi, Sunao, Manabe
openaire   +3 more sources

Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management of APAP poisoning indicated that management of APAP‐ER
Kyunghee Yang   +8 more
wiley   +1 more source

Hetrombopag: A promising thrombopoietin receptor agonist for the treatment of primary and secondary immune thrombocytopenia

open access: yesRheumatology &Autoimmunity, EarlyView.
This review seeks to provide a thorough synthesis of the existing literature on the role of thrombopoietin receptor agonists in the treatment of primary and secondary immune thrombocytopenia, with particular emphasis on the compound Hetrombopag. Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by a platelet count below
Jiaqi Hu   +8 more
wiley   +1 more source

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