Results 181 to 190 of about 79,419 (267)

Afatinib Versus Osimertinib for Non‐Small Cell Lung Cancer With Uncommon EGFR Mutations: Real‐World Outcomes

Cancer Science, EarlyView.
Afatinib and osimertinib showed broadly comparable survival outcomes as first‐line therapy for NSCLC with uncommon EGFR mutations. Treatment may be individualized by mutation subtype, while adding immune checkpoint inhibition to platinum doublet after EGFR‐TKI showed no clear benefit.
Yutaro Nagano, Hiroshi Yokouchi, Ryota Saito, Osamu Honjo, Toshiyuki Sumi, Takayuki Kaburagi, Kenichiro Ito, Yasuyuki Ikezawa, Keiki Yokoo, Hajime Kikuchi, Sayaka Kudo, Masami Yamazoe, Ryota Shigaki, Keita Tagami, Toshiyuki Tenma, Tatsuru Ishikawa, Mamoru Takahashi, Takaaki Sasaki, Hajime Asahina, Shiro Hinotsu, Hirofumi Chiba, Satoshi Oizumi   +21 more
wiley   +1 more source

Sodium valproate: balancing benefits and risks especially in people of childbearing potential. [PDF]

Aust Prescr
McLaughlin D.
europepmc   +1 more source

A Proposed Clinical Diagnostic Framework for Short Telomere Syndrome

Clinical Genetics, EarlyView.
We propose a phenotype‐based diagnostic framework for short telomere syndrome that integrates age‐adjusted telomere length, phenotypic manifestations, and genetic findings, where available. The framework is intended to guide clinical evaluation, longitudinal surveillance, and individualized management while acknowledging limitations in current telomere
Andrew Courtwright, Richard A. King, Jennie Vagher, Cate T. Levy, Juan Gallegos F. Orozco, Luis FZ Batista, Afaf Osman, Srinivas Tantavahi, Mary Beth Scholand   +8 more
wiley   +1 more source

Ciprofloxacin-Induced Guillain-Barré Syndrome, Posterior Reversible Encephalopathy Syndrome, Hepatotoxicity, and Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Case Report. [PDF]

Cureus
Zammar K, Al-Emadi A, Safan A, Mesraoua B, Melikyan G.   +4 more
europepmc   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Nivolumab-Associated Acute Liver Failure: A Report of Two Cases. [PDF]

Cureus
Shenoi LR, Banday SZ, Acharya K.
europepmc   +1 more source

Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Orforglipron is a novel small‐molecule, once daily oral non‐peptide GLP‐1 receptor agonist. The hepatic safety profile in adults with obesity or overweight and/or type 2 diabetes (T2D) across seven orforglipron Phase 3 clinical trials was assessed.
Sean Wharton, Adam Stefanski, Jiaxun Chen, Girish Rao, Elvis Asare Twum, Max Denning   +5 more
wiley   +1 more source

Cholestatic Hepatitis in Young Migrants Exposed to Fuel Vapours: An Emerging Toxicity From the Mediterranean Sea

Acta Paediatrica, EarlyView.
Antonio Corsello, Simone Maria Calogero Gramaglia, Giuseppe Gramaglia, Gerlando Verruso, Giusy Ranucci   +4 more
wiley   +1 more source