Results 171 to 180 of about 79,419 (267)

Establishment of a Thioacetamide-Induced Hepatotoxicity Model in Synanthropic Rats with Translational Relevance. [PDF]

Diseases
Valdivia Quispe LA, Velasco Lopez L, Díaz Obregón DZ, Murillo Carrasco AG, de León Delgado J, Lloja Lozano L, Pando Mayta JW, Rivera Prado AB, Yparraguirre Salcedo KG, Carbajal Zegarra VH, Ramírez Atencio CW.   +10 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Reversible massive ascites from amiodarone hepatotoxicity. [PDF]

Oxf Med Case Reports
Nishimura Y, Horiuchi Y, Tanabe K.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

A DPHV-liver module recapitulates AML infiltration and chemotherapy-induced hepatotoxicity with translational utility. [PDF]

Sci Adv
Deng B, Ma Y, Huang W, Xian X, Ding Y, Lu Y, Yang Y, Guo W, Mao L, Wang X, Jiang E, Ma X, Huang P.   +12 more
europepmc   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

An International Phase 4 Study of Lenvatinib and Sorafenib in Real-World Patients with Unresectable Hepatocellular Carcinoma: Final Analysis. [PDF]

Liver Cancer
Peck-Radosavljevic M, Abdelgafur A, Granito A, Gasbarrini A, Ma YT, Mena E, Lledó-Navarro JL, Presa J, Weinmann A, Levy MT, Pellicelli A, Waldschmidt DT, Sørensen HT, Goyal L, Ren M, Saal H, Okpara CE, Meyer T.   +17 more
europepmc   +1 more source

Assessing Correlation of Quantitative Technetium‐99m Sestamibi Uptake in Thyroid Scintigraphy With Treatment Duration in Amiodarone‐Induced Thyrotoxicosis

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Ray Wang, Nathan Better, Dinesh Sivaratnam, James Westcott, Simon Forehan, David A. Pattison, Spiros Fourlanos   +6 more
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Toxicokinetics under extracorporeal clearance and temporal dissociation of hepatotoxicity and coagulopathy in ACDMB poisoning: Two index cases. [PDF]

Toxicol Rep
Jin K, Wang P, Yang X, Zhang X, Huang T, Qiu Y, Li M, Wang Y, Ma X.   +8 more
europepmc   +1 more source