Results 231 to 240 of about 160,647 (335)

The conversion of evodiamine-induced hepatotoxicity into a therapeutic effect on colonitis: insight from the liver-gut axis mediated by PPAR/NF-κB/ZO-1/caspase-3 pathway. [PDF]

Chin Med
Zhao C, Fan Q, Dong Y, Sun S, Zhang Y, Yao H, Ren H, Li J, Qiao C, Li J, She G, Lin R.   +11 more
europepmc   +1 more source

Hepatoprotective Effects of Various Solvent Extracted Samples of Paeonia Emodi (wall) in Mice with Paracetamol-Induced Hepatotoxicity

, 2018
Liaqat Zeb, Muhammad Shafiq, Asaf Khan, Ali Akbar, Muhammad Ishfaq Ahmad, Abdul Majid   +5 more
openalex   +2 more sources

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management

ChemistryOpen, EarlyView.
Teucrium polium shows antidiabetic activity with its phytochemical composition and biological activities. The essential oil is rich in carvacrol, thymol, γ‐terpinene, and o‐cymene, while the aqueous and hydroethanolic extracts are characterized by poliumoside, verbascoside, isorhamnetin‐3‐O‐rutinoside, and apigenin‐7‐rutinoside. Antioxidant activity is
Hajar El Ouadni, Aziz Drioiche, Fadoua El Makhoukhi, Omkulthom Al kamaly, Hannou Zerkani, Smail Amalich, Imane Tagnaout, Mohamed Radi, Yahya Cherrah, Touriya Zair, Katim Alaoui   +10 more
wiley   +1 more source

Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors. [PDF]

BMC Gastroenterol
Hioki T, Imoto K, Goya T, Azuma Y, Horiuchi A, Aoyagi T, Takahashi M, Oda Y, Kato M, Kohjima M, Tanaka M, Ogawa Y.   +11 more
europepmc   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

Suspected Pyridostigmine-Related Hepatotoxicity. [PDF]

ACG Case Rep J
DiBenedetto L, Wong V, Nasir U, Asif B.
europepmc   +1 more source

Ameliorative Effects of Pomegranate Peel Extract on Hepatotoxicity Induced by Carbon Tetrachloride in Mice

, 2016
Mona Rahman, Hanan Ali, Mahmoud Okail, Nahed Mohamed, M.D. EMAN I. EL-DESOKI MAHMOUD DALIA F. EMAM, H-Y Kim, J-K Kim, J-H Choi, J-Y Jung, W-Y Oh, D Kim, F Morisco, P Vitaglione, D Amoruso, B Russo, V Fogliano, N Caporaso, D Prashanth, M Asha, A Amit, B Dutta, I Rahman, T Das, K Gharzouli, S Khennouf, S Amira, A Gharzouli, E Lansky, R Newman, R Singh, Chidambara Murthy, K Jayaprakasha, G, A Gomez-Caravaca, V Verardo, M Toselli, A Segura-Carretero, A Fernandez-Gutierrez, M Caboni, M Ibrahium, Chidambara Murthy, K Reddy, V Veigas, J Murthy, U, M Jeune, J Kumi-Diaka, J Brown, R Tzulker, I Glazer, I Bar-Ilan, D Holland, M Aviram, R Amir, H Toklu, O Sehirli, G Sener, M Dumlu, F Ercan, N Gedik, H Toklu, ehirli, H zyurt, E Ekiolu-Demiralp, etinel, H ahin, Kz-Y Xu, C Zhu, M Kim, J Yamahara, Y Li, A El-Rashedy, S Belal, H Osman, G Shehab, M Osman, M Ahmed, S Mahfouz, S Elaby, H Sadia, Q Akter, R Afroz, T Siddika, X-L Wei, Fang R-T, Y-H Yang, X Bi, G-X -Y, Ren, A-L Luo, Chidambara Murthy, K Jayaprakasha, G Singh, R, M Ghasemi, M Azarnia, M Jamali, G Mirabolghasemi, S Nazarian, M Naghizadeh, G Avwioro   +99 more
openalex   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source