Results 231 to 240 of about 104,266 (306)

Hepatotoxic Compounds and Mechanisms of Polygonum Multiflorum: A Narrative Review of Recent Advances. [PDF]

Int J Mol Sci
Wang Y, Ren T, Zhang Y, Yuan L, Geng X.
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Incidence, risk factors, and outcomes of anti-tuberculosis drug-induced hepatotoxicity in people with and without HIV in Thailand and the Philippines. [PDF]

Asian Biomed (Res Rev News)
Atuel RCG, Gutierrez EA, Hiranburana N, Apornpong T, Ubolyam S, Gler MTS, Avihingsanon A, Gatechompol S, Kerr SJ.   +8 more
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Emphysema in an 11‐month‐old boy with alpha‐1 antitrypsin deficiency

Pediatric Investigation, EarlyView.
Pediatric development of emphysema in Alpha‐1 Antitrypsin Deficiency (A1ATD) has been rarely described. In this case report, we document an 11‐month boy with A1ATD phenotype PiZZ with basilar centrilobular emphysema, the earliest such documented case.
Irvin Yi, Rachel Williams, Leela Chandrasekar, Saif Al‐Qatarneh   +3 more
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Isolated Gamma-Glutamyltransferase Elevation During Statin Therapy: A Diagnostic Pitfall and a Stepwise Management Framework to Prevent Unnecessary Discontinuation. [PDF]

Clin Case Rep
Yang J, He Y, Zhang Z.
europepmc   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

<i>Sphingopyxis</i> sp. IM-1 Reduces Intact Microcystin-LR and Attenuates MC-LR-Associated Inflammatory Gene Expression in Hep3B Hepatocytes. [PDF]

Toxins (Basel)
Lad A, Bhatia M, Birbeck JA, Kuang A, Furr E, Westrick J, Seo Y, Kang DW, Kennedy DJ, Haller ST.   +9 more
europepmc   +1 more source

Olanzapine-Associated Hepatotoxicity in Bipolar Disorder: A Multicenter Real-World Study of Prevalence, Risk Factors, and Outcomes. [PDF]

Drug Des Devel Ther
Wang F, Lai X, Zhou S, Lin J, Xin H, Tao Z, Wang X, Zhang S, Liu Z, Tan H, Xiong Y.   +10 more
europepmc   +1 more source