Results 321 to 330 of about 146,077 (348)
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Hepatotoxicity of the thiazolidinediones
Clinics in Liver Disease, 2003Troglitazone, the first of the thiazolidinediones, caused severe hepatotoxicity including liver failure in several patients. It appears, however, that the thiazolidinediones as a class are not as hepatotoxic as troglitazone. Comparative data at comparable dates of usage indicate that pioglitazone and rosiglitazone are not significant hepatotoxins. This
Keith G. Tolman, Jane Chandramouli
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Acta Medica Scandinavica, 1986
ABSTRACT.Amiodarone has proved very effective in the treatment of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its serious side‐effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given.
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ABSTRACT.Amiodarone has proved very effective in the treatment of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its serious side‐effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given.
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Journal of Clinical Psychopharmacology, 1997
Two hundred thirty-eight patients treated with either haloperidol or clozapine were investigated to shed more light on the incidence and severity of antipsychotic-induced liver enzyme increase. Serum glutamic-pyruvic transaminase (SGPT) increase was most frequently seen in both treatment groups.
Martin Kurz +5 more
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Two hundred thirty-eight patients treated with either haloperidol or clozapine were investigated to shed more light on the incidence and severity of antipsychotic-induced liver enzyme increase. Serum glutamic-pyruvic transaminase (SGPT) increase was most frequently seen in both treatment groups.
Martin Kurz +5 more
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Hepatotoxicity of Mercaptopurine
JAMA, 1964In a study of 49 leukemic patients, jaundice occurred in 16 of 38 who were treated with mercaptopurine (6-mercaptopurine), but only in one of 11 not receiving the drug. In eight patients jaundice cleared up rapidly on cessation of mercaptopurine therapy, and there was a recurrence of jaundice in two who were rechallenged with the drug.
Israel Davidsohn, Morton Einhorn
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Hepatotoxicity of dichloromethane
Forensic Science International, 1988We studied hepatotoxicity of dichloromethane using primary cultures of parenchymal cells (hepatocyte) from adult rat livers. The production of carbon monoxide from dichloromethane increased with time, the increased cell number, and the concentration of dichloromethane.
Kenji Mizutani +2 more
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Papaverine — Hepatotoxic or Not?*
Journal of the American Geriatrics Society, 1973ABSTRACT: Papaverine hydrochloride (Pavabid) has been recommended in geriatric practice for increasing cerebral blood flow and improving mental functioning. However, reports of hepatotoxicity as indicated by physical signs and symptoms and elevated levels of serum alkaline phosphatase, serum glutamic oxalacetic transaminase and serum glutamic pyruvic ...
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Clinics in Liver Disease, 2003
Unlike the bulk of medications, described in this fascicle, that cause liver injury in humans, acetaminophen is a non-prescription drug that can be purchased in drug stores and supermarkets without a physician's involvement. Death or severe injury is far more likely to occur with its use than with all the other medications considered in this study ...
Matthew Q, Bromer, Martin, Black
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Unlike the bulk of medications, described in this fascicle, that cause liver injury in humans, acetaminophen is a non-prescription drug that can be purchased in drug stores and supermarkets without a physician's involvement. Death or severe injury is far more likely to occur with its use than with all the other medications considered in this study ...
Matthew Q, Bromer, Martin, Black
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Current Protocols in Toxicology, 2001
AbstractThis overview presents some of the salient features of liver biology and physiology that form the basis for a variety of experimental tools that are used for the study of chemical histopathology. Prevalence and risk of heptatoxicity are examined among a subset of chemicals from the EPA IRIS database.
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AbstractThis overview presents some of the salient features of liver biology and physiology that form the basis for a variety of experimental tools that are used for the study of chemical histopathology. Prevalence and risk of heptatoxicity are examined among a subset of chemicals from the EPA IRIS database.
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Hepatotoxicity of Acetaldehyde
1980All known pathways of ethanol oxidation in the liver result in production of acetaldehyde. Until recently, however, the fate of this metabolite of ethanol has been rather neglected because of methodological difficulties in its measurement. However, recent technological advancements have permitted the development of acceptable methods to detect ...
M. Salaspuro +5 more
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Clinics in Liver Disease, 2002
Drug-induced liver disease is a relatively common, but often unrecognized, cause of liver injury, primarily because the diagnosis is often not entertained clinically. In addition, drugs are great imitators, capable of producing nearly any clinical scenario and histopathologic lesion.
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Drug-induced liver disease is a relatively common, but often unrecognized, cause of liver injury, primarily because the diagnosis is often not entertained clinically. In addition, drugs are great imitators, capable of producing nearly any clinical scenario and histopathologic lesion.
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