Results 251 to 260 of about 4,021 (283)
Some of the next articles are maybe not open access.
Removal of a potent cyanobacterial hepatotoxin by peat
Journal of Environmental Science and Health, Part A, 2010Microcystins (cyclic heptapeptides), produced by a number of freshwater cyanobacteria, are of health concern in potable water supplies. In this article, the adsorptive removal of microcystin-RR (MCRR) from the aqueous solution by a low-cost adsorbent, peat, was investigated. The BET surface area of peat was found to be 12.134 m2/g.
Sathishkumar, O. +4 more
openaire +2 more sources
Are Mould Hepatotoxins Responsible for Kava Hepatotoxicity?
Phytotherapy Research, 2012Previous studies with kava components such as kavalactones, pipermethystine and flavokavain B have demonstrated hepatotoxicity from these constituents. Regardless, there has recently been speculation that adulterants or impurities such as the mould hepatotoxin aflatoxin are a more likely cause of kava hepatotoxicity, despite a paucity of supporting ...
Anthony, Rowe, Iqbal, Ramzan
openaire +2 more sources
Identification of hepatotoxin‐producing cyanobacteria by DNA‐chip
Environmental Microbiology, 2008Summary We developed a new tool to detect and identify hepatotoxin‐producing cyanobacteria of the genera Anabaena , Microcystis , Planktothrix , Nostoc and
Anne Rantala +4 more
openaire +3 more sources
Hepatotoxin-induced hypertaurinuria: a proton NMR study
Archives of Toxicology, 1990The urinary excretion of taurine by rats after dosing with various hepatotoxins has been investigated by 1H NMR spectroscopy. After single hepatotoxic doses of hydrazine, carbon tetrachloride, 1-naphthylisothiocyanate, or thioacetamide there was biochemical and histopathological evidence of hepatic damage. Proton NMR spectroscopy of the urine collected
S M, Sanins +3 more
openaire +2 more sources
Effect of hyperoxia on liver necrosis induced by hepatotoxins
Virchows Archiv B Cell Pathology Including Molecular Pathology, 1986We have tested the effects of hyperbaric oxygen on necrosis of rat liver induced by the administration of several toxins. The extent of liver necrosis was determined 24 h after the administration of the toxins by measurement of serum levels of alanine and aspartate amino-transferases and by histologic and ultrastructural analyses.
L, Marzella, K, Muhvich, R A, Myers
openaire +2 more sources
The effect of some hepatotoxins on the sulphoxidation of cimetidine in rat
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1986Sulphoxidation of cimetidine was investigated in male and female rats after pretreatment with the hepatotoxins allyl alcohol, dl-ethionine, thioacetamide and carbon tetrachloride. There was a marked sex difference in cimetidine sulphoxidation in response to the hepatotoxin pretreatment.
P A, Dixon, A U, Udeagha
openaire +2 more sources
Toxicity of hepatotoxins: new insights into mechanisms and therapy
Expert Opinion on Investigational Drugs, 1999Liver injury caused by hepatotoxins, such as carbon tetrachloride (CCl4), ethanol, and acetaminophen (APAP), is characterised by varying degrees of hepatocyte degeneration and cell death via either apoptosis or necrosis. The generation of reactive intermediate metabolites from the metabolism of hepatotoxins, and the occurrence of reactive oxygen ...
J, Wu, A, Danielsson, M A, Zern
openaire +2 more sources
Disposition of the hepatotoxin α-naphthylisothiocyanate (ANIT) in the rat
Toxicology and Applied Pharmacology, 1970Abstract The disposition of ANIT was investigated in the rat by examining quantitatively the tissue, organ, and subcellular distribution as well as the excretion pattern, of 14C at selected times after ANIT-14C administration. Approximately 70% of the radioactive material was absorbed from the gastrointestinal tract within 24 hr and was found widely ...
F, Capizzo, R J, Roberts
openaire +2 more sources
OXIDATIVE BIOACTIVATION OF HALOFORMS INTO HEPATOTOXINS
1980This chapter discusses the oxidative bioactivation of haloforms into hepatotoxins. The hepatotoxin chloroform (CHCl 3 ) is converted to phosgene (COCl 2 ) by rat liver microsomes and in living rats. The reaction is oxygen dependent and appears to be catalyzed by cytochrome P-450.
L.R. Pohl +3 more
openaire +1 more source
Degradation of the cyanobacterial hepatotoxin microcystin by aquatic bacteria
Natural Toxins, 1994AbstractBacterial degradation of the cyanobacterial cyclic peptide hepatotoxin microcystin was confirmed in natural waters and by isolated laboratory strains. Degradation of 1 mg L−1 microcystin LR typically began 2‐8 days after addition to surface water samples. At concentrations greater than 1 mg L1 there was an initial slow removal of microcystin LR,
Jones, Gary J. +3 more
openaire +5 more sources