Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice. [PDF]
PLoS PathogensHepatitis A virus (HAV) is a globally important cause of enterically-transmitted hepatitis. It is one of 9 distinct Hepatovirus species in the Picornaviridae, among which phylogenetic reconstructions suggest multiple past host species jumps.
Ichiro Misumi +9 more
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Divergent Genotype of Hepatitis A Virus in Alpacas, Bolivia, 2019 [PDF]
Emerging Infectious Diseases, 2023 Hepatitis A virus (HAV) is a common human pathogen found exclusively in primates. In a molecular and serologic study of 64 alpacas in Bolivia, we detected RNA of distinct HAV in ≈9% of animals and HAV antibodies in ≈64%.
Talitha Veith +11 more
doaj +2 more sources
Identification and Genomic Characterization of Two Novel Hepatoviruses in Shrews from Yunnan Province, China [PDF]
VirusesHepatitis A virus (HAV), a member of the genus Hepatovirus (Picornaviridae HepV), remains a significant viral pathogen, frequently causing enterically transmitted hepatitis worldwide. In this study, we conducted an epidemiological survey of HepVs carried
Yi Tang +11 more
doaj +2 more sources
Discovery of a Novel Hepatovirus (
mBio, 2015 Describing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus ...
S. J. Anthony +13 more
doaj +5 more sources
Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responses [PDF]
Science AdvancesThe overexpression and misfolding of viral proteins in the endoplasmic reticulum (ER) may cause cellular stress, thereby inducing a cytoprotective, proteostatic host response involving phosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eIF2α).
Takayoshi Shirasaki +2 more
exaly +4 more sources
Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells [PDF]
VirusesBoth hepatitis B virus (HBV), an hepadnavirus with a DNA genome, and hepatitis A virus (HAV), a picornavirus, require the TRAMP-like host ZCCHC14-TENT4 complex for efficient replication.
You Li +9 more
doaj +2 more sources
MBio, 2017 Receptor molecules play key roles in the cellular entry of picornaviruses, and TIM1 (HAVCR1) is widely accepted to be the receptor for hepatitis A virus (HAV), an unusual, hepatotropic human picornavirus.
Anshuman Das +2 more
exaly +3 more sources
Identification and characterization of multiple novel picornaviruses in fecal samples of bar-headed goose [PDF]
Frontiers in MicrobiologyIntroductionThe bar-headed goose (Anser indicus), one of the most well-known high-altitude birds, is renowned for its adaptation to high-altitude environments.
Yijie Sun +9 more
doaj +2 more sources
Conservative Treatment of HAV-Associated Acalculous Acute Cholecystitis in an Adult: A Case Report. [PDF]
Case Rep MedHepatitis A virus (HAV) is a viral infection that can present with a wide range of clinical manifestations, including rare complications such as acute acalculous cholecystitis (AAC). We present the case of a 31‐year‐old woman who arrived at the emergency department with severe epigastric pain, fever, early satiety, nausea, and vomiting.
Medina-Ramirez SA +3 more
europepmc +2 more sources
Clinical progress note: Hepatitis A virus. [PDF]
J Hosp MedVisual Abstract Abstract Despite a decline in hepatitis A virus (HAV) incidence following vaccine introduction, HAV remains a public health concern in the United States. Recent multi‐state outbreaks have demonstrated that HAV can re‐emerge and highlight inequities in vaccine coverage or access, outbreak response, and in those with social or health risk
McCluskey JM, Bockrath RA, Jhaveri R.
europepmc +2 more sources