Results 161 to 170 of about 281,370 (287)

Spatial and Proteolytic Determinants of Therapeutic Potential in HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Deqian Xie, Wei Dai, Guangzhen Wu
wiley   +1 more source

Completion vs. early discontinuation of chemotherapy and the impact on 5‐year all‐cause mortality in women treated for early‐stage breast cancer from 2015 to 2020: A cohort study using a target trial emulation approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Chemotherapy is given for early‐stage breast cancer; however, some patients discontinue before completing all planned cycles. This study investigated the impact of early chemotherapy discontinuation on treatment outcomes. Methods This retrospective cohort study used a target trial emulation framework to conduct a causal analysis of the all‐
Luke Steventon, Chengsheng Ju, Kenneth K. C. Man, Rebecca Roylance, Diego Ottaviani, Chiara Creed, Michal Sladkowski, Alec Wisner, Li Wei, Pinkie Chambers   +9 more
wiley   +1 more source

Advances in Targeted Therapy for Human Epidermal Growth Factor Receptor 2-Low Tumors: From Trastuzumab to Antibody-Drug Conjugates. [PDF]

World J Oncol
Zheng ZN, Ye XH, Shen XB, Li T, Guo J.
europepmc   +1 more source

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial. [PDF]

Signal Transduct Target Ther
Yao H, Yan M, Tong Z, Wu X, Yin Y, Ryu MH, Park JJ, Jiang S, Kim JH, Wang S, Zhong Y, Voskoboynik M, Zhang J, Kaubisch A, Liu C, Chen Y, Im SA, Wu L, Liu Y, Ganju V, Barve M, Li H, Yao G, Yang M, Bao L, Zhao Y, Zhao J, Zhao K, Shen Y, Rong S, Zhu X, Song E.   +31 more
europepmc   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

A Systematic Review of Mechanisms, Incidence, and Management of Trastuzumab Deruxtecan Induced ILD/Pneumonitis in Solid Tumors

Drug Design, Development and Therapy
Dehua Liao,1 Jiwen Zhang,1,2 Ting Yan,1 Yun Chen,1 Yilan Fu,1 Ning Xie,3,* Minghui Long1,* 1Department of Pharmacy, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s ...
Liao D, Zhang J, Yan T, Chen Y, Fu Y, Xie N, Long M   +6 more
doaj  

A Computational Workflow for Cell Line Profiling by Imaging Mass Cytometry

Cytometry Part A, EarlyView.
ABSTRACT In single‐cell spatial phenotyping biology, imaging mass cytometry (IMC) stands out as a cutting‐edge, highly multiplexed technology driving discoveries across various disease areas. In vitro profiling relies on tumor‐derived cancer cell lines, known for their diverse morphologies and phenotypes.
Alexandre Bouzekri, Amanda Esch, Olga Ornatsky   +2 more
wiley   +1 more source

HER2 [PDF]

, 2019
openaire   +1 more source