Loss of Nuclear ARID-1A Expressions Is Associated with Hormone Receptor Status in Breast Cancers
European Journal of Breast Health, 2019 Objective:Breast cancer is the most common cancer among women worldwide. Adenine thymine-rich interactive domain 1A (ARIDIA) is a tumor suppressor gene involved in chromatin remodeling and it encodes the ARIDIA protein. Recent studies have shown the loss
Melek Ünçel +6 more
doaj +1 more source
South Asian Journal of Cancer, 2022 Biren Parikh Introduction Hormonal status and HER2 expression are valuable biomarkers and dictate the management of the patients diagnosed with invasive breast cancer (IBC).
B. R. Nagarjun +4 more
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Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
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Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]
, 2015 Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim +31 more
core +1 more source
[18F]FDG PET/CT volumetric biomarkers for non-invasive prediction of HER2 expression in breast cancer patients [PDF]
Asia Oceania Journal of Nuclear Medicine and BiologyObjective(s): to investigate the capability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT) derived volumetric parameters to predict human epidermal growth factor receptor 2 (HER2) status in breast cancer ...
Mai ELahmadawy +5 more
doaj +1 more source
Targeting the Ets Binding Site of the HER2/neu Promoter with Pyrrole-Imidazole Polyamides [PDF]
, 2000 Three DNA binding polyamides (1-3) were synthesized that bind with high affinity (Ka = 8.7·10^9 M^-1 to 1.4·10^10 M^-1) to two 7-base pair sequences overlapping the Ets DNA binding site (EBS; GAGGAA) within the regulatory region of the HER2/neu proximal ...
Beerman, Terry A. +6 more
core +1 more source
HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer [PDF]
American Journal of Clinical Pathology, 2017 Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using a novel gene protein assay (GPA), which can ...
Yanjun, Hou, Hiroaki, Nitta, Zaibo, Li
openaire +2 more sources
Molecular & Cellular Oncology, 2017 Insulin receptor substrate 4 (IRS4) belongs to a family of cytoplasmic docking proteins mediating signals from cell surface receptors to downstream effectors.
Gerjon J. Ikink, John Hilkens
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Anti‐proliferative effects of pentagamaboronon‐0‐sorbitol on HER2‐overexpressing breast cancer cells
Indonesian Journal of Biotechnology, 2022 HER2‐positive breast cancer is an aggressive form of the disease that is associated with poor prognosis and chemo‐resistance. As such, investigation continues into the development of a new HER2‐targeted drug for breast cancer. This study investigated the
Lailatul Qodria +3 more
doaj +1 more source
Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients. [PDF]
, 2017 BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and ...
Arguello, David +4 more
core +1 more source